| Title | Meta-analysis identifies six new susceptibility loci for atrial fibrillation. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Ellinor PT, Lunetta KL, Albert CM, Glazer NL, Ritchie MD, Smith AV, Arking DE, Müller-Nurasyid M, Krijthe BP, Lubitz SA, Bis JC, Chung MK, Dörr M, Ozaki K, Roberts JD, J Smith G, Pfeufer A, Sinner MF, Lohman K, Ding J, Smith NL, Smith JD, Rienstra M, Rice KM, Van Wagoner DR, Magnani JW, Wakili R, Clauss S, Rotter JI, Steinbeck G, Launer LJ, Davies RW, Borkovich M, Harris TB, Lin H, Völker U, Völzke H, Milan DJ, Hofman A, Boerwinkle E, Chen LYee, Soliman EZ, Voight BF, Li G, Chakravarti A, Kubo M, Tedrow UB, Rose LM, Ridker PM, Conen D, Tsunoda T, Furukawa T, Sotoodehnia N, Xu S, Kamatani N, Levy D, Nakamura Y, Parvez B, Mahida S, Furie KL, Rosand J, Muhammad R, Psaty BM, Meitinger T, Perz S, Wichmann H-E, Witteman JCM, Kao LWH, Kathiresan S, Roden DM, Uitterlinden AG, Rivadeneira F, McKnight B, Sjögren M, Newman AB, Liu Y, Gollob MH, Melander O, Tanaka T, Stricker B CH, Felix SB, Alonso A, Darbar D, Barnard J, Chasman DI, Heckbert SR, Benjamin EJ, Gudnason V |
| Secondary Authors | Kääb S |
| Journal | Nat Genet |
| Volume | 44 |
| Issue | 6 |
| Pagination | 670-5 |
| Date Published | 2012 Apr 29 |
| ISSN | 1546-1718 |
| Keywords | Adolescent, Adult, Aged, Aged, 80 and over, Asian Continental Ancestry Group, Atrial Fibrillation, Child, Child, Preschool, European Continental Ancestry Group, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Infant, Infant, Newborn, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Young Adult |
| Abstract | Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P |
| DOI | 10.1038/ng.2261 |
| Alternate Journal | Nat Genet |
| PubMed ID | 22544366 |
| PubMed Central ID | PMC3366038 |
| Grant List | R21 DA027021 / DA / NIDA NIH HHS / United States K24 HL105780 / HL / NHLBI NIH HHS / United States R01 HL092217 / HL / NHLBI NIH HHS / United States R01 HL104156 / HL / NHLBI NIH HHS / United States U19 HL065962 / HL / NHLBI NIH HHS / United States U19 HL065962-12 / HL / NHLBI NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States R01 HL090620 / HL / NHLBI NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States L30 HL097675 / HL / NHLBI NIH HHS / United States R01 HL092217-04 / HL / NHLBI NIH HHS / United States R21 HL106092 / HL / NHLBI NIH HHS / United States |