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Incident gout in women and association with obesity in the Atherosclerosis Risk in Communities (ARIC) Study.

TitleIncident gout in women and association with obesity in the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2012
AuthorsMaynard JW, McAdams DeMarco MA, Baer AN, Köttgen A, Folsom AR, Coresh JJ
Secondary AuthorsGelber AC
JournalAm J Med
Volume125
Issue7
Pagination717.e9-717.e17
Date Published2012 Jul
ISSN1555-7162
KeywordsBody Mass Index, Cohort Studies, Female, Gout, Humans, Incidence, Middle Aged, Obesity, United States, Waist-Hip Ratio, Weight Gain
Abstract

BACKGROUND: We hypothesized that women with early- and mid-adult life obesity, as well as high mid-adult life waist-to-hip ratios, and high weight gain during adulthood, experience a greater incidence of gout.

METHODS: We examined the incidence of gout in the Atherosclerosis Risk in Communities Study, a population-based biracial cohort comprised of individuals aged 45-65 years at baseline (1987-1989). A total of 6263 women without prior history of gout were identified. We examined the association of body mass index (BMI) and obesity at cohort entry and at age 25 years, waist-to-hip ratio, and weight change with gout incidence (1996-1998).

RESULTS: Over 9 years of follow-up, 106 women developed gout. The cumulative incidence of gout, by age 70 years, according to BMI category at baseline of

CONCLUSIONS: In a large cohort of black and white women, obesity in early- and mid-adulthood, and weight gain during this interval, were each independent risk factors for incident gout in women.

DOI10.1016/j.amjmed.2011.11.018
Alternate JournalAm J Med
PubMed ID22571781
PubMed Central IDPMC3383456
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
1KL2RR025006 / RR / NCRR NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
T32 HL007024 / HL / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
KL2 RR025006 / RR / NCRR NIH HHS / United States
5T32HL007024 / HL / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States