Title | A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Manning AK, Hivert M-F, Scott RA, et al. |
Corporate Authors | DIAbetes Genetics Replication and Meta-analysis(DIAGRAM) Consortium, Multiple Tissue Human Expression Resource(MUTHER) Consortium |
Journal | Nat Genet |
Volume | 44 |
Issue | 6 |
Pagination | 659-69 |
Date Published | 2012 May 13 |
ISSN | 1546-1718 |
Keywords | Blood Glucose, Body Mass Index, Cholesterol, HDL, Diabetes Mellitus, Type 2, Genome-Wide Association Study, Humans, Insulin, Insulin Resistance, Polymorphism, Single Nucleotide |
Abstract | Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P |
DOI | 10.1038/ng.2274 |
Alternate Journal | Nat Genet |
PubMed ID | 22581228 |
PubMed Central ID | PMC3613127 |
Grant List | MC_UP_A100_1003 / / Medical Research Council / United Kingdom G19/35 / / Medical Research Council / United Kingdom G0100222 / / Medical Research Council / United Kingdom MC_U127561128 / / Medical Research Council / United Kingdom R01 DK072193 / DK / NIDDK NIH HHS / United States S10 RR029392 / RR / NCRR NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States MC_U137686857 / / Medical Research Council / United Kingdom R01 HL105756 / HL / NHLBI NIH HHS / United States MC_U106179471 / / Medical Research Council / United Kingdom P30 DK063491 / DK / NIDDK NIH HHS / United States R37 MH059490 / MH / NIMH NIH HHS / United States P30 DK020572 / DK / NIDDK NIH HHS / United States MC_U127592696 / / Medical Research Council / United Kingdom 091551 / / Wellcome Trust / United Kingdom R01 DK093757 / DK / NIDDK NIH HHS / United States R01 DK078616 / DK / NIDDK NIH HHS / United States CZB/4/710 / / Chief Scientist Office / United Kingdom G8802774 / / Medical Research Council / United Kingdom G0902037 / / Medical Research Council / United Kingdom MR/J006742/1 / / Medical Research Council / United Kingdom MC_U106179472 / / Medical Research Council / United Kingdom G1002084 / / Medical Research Council / United Kingdom MC_PC_U127592696 / / Medical Research Council / United Kingdom G0701863 / / Medical Research Council / United Kingdom K24 DK080140 / DK / NIDDK NIH HHS / United States 090532 / / Wellcome Trust / United Kingdom MC_PC_U127561128 / / Medical Research Council / United Kingdom G0900339 / / Medical Research Council / United Kingdom RG/07/008/23674 / / British Heart Foundation / United Kingdom |