Pulse lineResearch With Heart Logo

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.

TitleStratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
Publication TypeJournal Article
Year of Publication2012
AuthorsPerry JRB, Voight BF, Yengo L, Amin N, Dupuis J, Ganser M, Grallert H, Navarro P, Li M, Qi L, Steinthorsdottir V, Scott RA, Almgren P, Arking DE, Aulchenko Y, Balkau B, Benediktsson R, Bergman RN, Boerwinkle E, Bonnycastle L, Burtt NP, Campbell H, Charpentier G, Collins FS, Gieger C, Green T, Hadjadj S, Hattersley AT, Herder C, Hofman A, Johnson AD, Köttgen A, Kraft P, Labrune Y, Langenberg C, Manning AK, Mohlke KL, Morris AP, Oostra B, Pankow J, Petersen A-K, Pramstaller PP, Prokopenko I, Rathmann W, Rayner W, Roden M, Rudan I, Rybin D, Scott LJ, Sigurdsson G, Sladek R, Thorleifsson G, Thorsteinsdottir U, Tuomilehto J, Uitterlinden AG, Vivequin S, Weedon MN, Wright AF, Hu FB, Illig T, Kao L, Meigs JB, Wilson JF, Stefansson K, van Duijn C, Altschuler D, Morris AD, Boehnke M, McCarthy MI, Froguel P, Palmer CNA, Wareham NJ, Groop L, Frayling TM
Secondary AuthorsCauchi S
Corporate AuthorsMAGIC, DIAGRAM Consortium, GIANT consortium
JournalPLoS Genet
Volume8
Issue5
Paginatione1002741
Date Published2012 May
ISSN1553-7404
KeywordsAged, Alleles, Asian Continental Ancestry Group, Body Mass Index, Case-Control Studies, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, High Mobility Group Proteins, Humans, Laminin, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Risk Factors
Abstract

Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic predisposition to the disease may be different in lean (BMI

DOI10.1371/journal.pgen.1002741
Alternate JournalPLoS Genet
PubMed ID22693455
PubMed Central IDPMC3364960
Grant ListR01 DK078616 / DK / NIDDK NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
CA54281 / CA / NCI NIH HHS / United States
092447/Z/10/Z / / PHS HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
CZB/4/710 / / Chief Scientist Office / United Kingdom
P01CA089392 / CA / NCI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
U01HG004726 / HG / NHGRI NIH HHS / United States
U01 HG004728 / HG / NHGRI NIH HHS / United States
U10AA008401 / AA / NIAAA NIH HHS / United States
R56 DK062370 / DK / NIDDK NIH HHS / United States
R01HL59367 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
U01HG004738 / HG / NHGRI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
U01HG004415 / HG / NHGRI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
U01 DE018993 / DE / NIDCR NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
U01HG004735 / HG / NHGRI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
MC_U127561128 / / Medical Research Council / United Kingdom
P01 CA089392 / CA / NCI NIH HHS / United States
R01 DK072193 / DK / NIDDK NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
083270/Z/07/Z / / Wellcome Trust / United Kingdom
Z01 CP010200 / / Intramural NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
U01HG004728 / HG / NHGRI NIH HHS / United States
U01HG004399 / HG / NHGRI NIH HHS / United States
U01 HG004415 / HG / NHGRI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
R01 DK062370 / DK / NIDDK NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
U01HG004422 / HG / NHGRI NIH HHS / United States
CA63464 / CA / NCI NIH HHS / United States
DK072193 / DK / NIDDK NIH HHS / United States
MC_U106179471 / / Medical Research Council / United Kingdom
R01DA013423 / DA / NIDA NIH HHS / United States
U01 HG004729 / HG / NHGRI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
U01 HG004422 / HG / NHGRI NIH HHS / United States
HHSN268201100012C / / PHS HHS / United States
R01HL087641 / HL / NHLBI NIH HHS / United States
MC_PC_U127592696 / / Medical Research Council / United Kingdom
HHSN268201100005I / HL / NHLBI NIH HHS / United States
R01 DA013423 / DA / NIDA NIH HHS / United States
R01 CA063464 / CA / NCI NIH HHS / United States
K24 DK080140 / DK / NIDDK NIH HHS / United States
U01DE018993 / DE / NIDCR NIH HHS / United States
090532 / / Wellcome Trust / United Kingdom
U01HG004423 / HG / NHGRI NIH HHS / United States
MC_PC_U127561128 / / Medical Research Council / United Kingdom
R01 CA054281 / CA / NCI NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
U01DE018903 / DE / NIDCR NIH HHS / United States
U01 CA063464 / CA / NCI NIH HHS / United States
064890 / / Wellcome Trust / United Kingdom
U01 DK062370 / DK / NIDDK NIH HHS / United States
U01HG004436 / HG / NHGRI NIH HHS / United States
U01HG004729 / HG / NHGRI NIH HHS / United States
DK062370 / DK / NIDDK NIH HHS / United States
U01 DE018903 / DE / NIDCR NIH HHS / United States
U01 HG004436 / HG / NHGRI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
U01 HG004735 / HG / NHGRI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
P30 DK020572 / DK / NIDDK NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
U01 HG004738 / HG / NHGRI NIH HHS / United States
U10 AA008401 / AA / NIAAA NIH HHS / United States
U01 HG004423 / HG / NHGRI NIH HHS / United States
MC_U127592696 / / Medical Research Council / United Kingdom
HHSN268201100006C / / PHS HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
U01 CA136792 / CA / NCI NIH HHS / United States
R37 CA054281 / CA / NCI NIH HHS / United States
U01 HG004399 / HG / NHGRI NIH HHS / United States
CA136792 / CA / NCI NIH HHS / United States
081682 / / Wellcome Trust / United Kingdom
G0601261 / / Medical Research Council / United Kingdom
R01HL086694 / HL / NHLBI NIH HHS / United States
U01 HG004726 / HG / NHGRI NIH HHS / United States