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Genome-wide association study of periodontal pathogen colonization.

TitleGenome-wide association study of periodontal pathogen colonization.
Publication TypeJournal Article
Year of Publication2012
AuthorsDivaris K, Monda KL, North KE, Olshan AF, Lange EM, Moss K, Barros SP, Beck JD
Secondary AuthorsOffenbacher S
JournalJ Dent Res
Volume91
Issue7 Suppl
Pagination21S-28S
Date Published2012 Jul
ISSN1544-0591
KeywordsAggregatibacter actinomycetemcomitans, Bacterial Load, Bacteroides, Calcium-Binding Proteins, Campylobacter rectus, Chronic Periodontitis, Core Binding Factor Alpha 1 Subunit, DNA, Bacterial, DNA-Binding Proteins, F-Box Proteins, Female, Fusobacterium nucleatum, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Interleukin-33, Interleukins, Male, Metagenome, Middle Aged, Nucleic Acid Hybridization, Periodontium, Porphyromonas gingivalis, Potassium Channels, Tandem Pore Domain, Prevotella intermedia, Prevotella nigrescens, Trans-Activators, Transcription Factors, Treponema denticola, Ubiquitin-Protein Ligases, Vesicle-Associated Membrane Protein 3, Zinc Fingers
Abstract

Pathological shifts of the human microbiome are characteristic of many diseases, including chronic periodontitis. To date, there is limited evidence on host genetic risk loci associated with periodontal pathogen colonization. We conducted a genome-wide association (GWA) study among 1,020 white participants of the Atherosclerosis Risk in Communities Study, whose periodontal diagnosis ranged from healthy to severe chronic periodontitis, and for whom "checkerboard" DNA-DNA hybridization quantification of 8 periodontal pathogens was performed. We examined 3 traits: "high red" and "high orange" bacterial complexes, and "high" Aggregatibacter actinomycetemcomitans (Aa) colonization. Genotyping was performed on the Affymetrix 6.0 platform. Imputation to 2.5 million markers was based on HapMap II-CEU, and a multiple-test correction was applied (genome-wide threshold of p

DOI10.1177/0022034512447951
Alternate JournalJ Dent Res
PubMed ID22699663
PubMed Central IDPMC3383103
Grant ListUL1RR025005 / RR / NCRR NIH HHS / United States
R01DE021418 / DE / NIDCR NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
R01 DE011551 / DE / NIDCR NIH HHS / United States
P30 ES010126 / ES / NIEHS NIH HHS / United States
R01HL59367 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HSN268201100012C / / PHS HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
R01 ES014843 / ES / NIEHS NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
R01HL087641 / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
R01DE11551 / DE / NIDCR NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States
R24 HD050924 / HD / NICHD NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
P30ES010126 / ES / NIEHS NIH HHS / United States
R01HL086694 / HL / NHLBI NIH HHS / United States
R01 DE021418 / DE / NIDCR NIH HHS / United States