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Association between cardiovascular disease risk factors and occurrence of venous thromboembolism. A time-dependent analysis.

TitleAssociation between cardiovascular disease risk factors and occurrence of venous thromboembolism. A time-dependent analysis.
Publication TypeJournal Article
Year of Publication2012
AuthorsWattanakit K, Lutsey PL, Bell EJ, Gornik H, Cushman M, Heckbert SR, Rosamond WD
Secondary AuthorsFolsom AR
JournalThromb Haemost
Volume108
Issue3
Pagination508-15
Date Published2012 Sep
ISSN2567-689X
KeywordsAlcohol Drinking, Atherosclerosis, Cardiovascular Diseases, Comorbidity, Diabetes Mellitus, Female, Follow-Up Studies, Hormone Replacement Therapy, Humans, Hyperlipidemias, Hypertension, Incidence, Male, Middle Aged, Motor Activity, Obesity, Proportional Hazards Models, Prospective Studies, Risk Factors, Smoking, Time Factors, United States, Venous Thromboembolism
Abstract

Apart from obesity, it remains controversial whether atherosclerosis and its cardiovascular risk disease (CVD) factors are associated with risk of venous thromboembolism (VTE). Using data from the Atherosclerosis Risk in Communities study (ARIC), we evaluated associations between CVD risk factors and incident VTE in a cohort of 15,340 participants who were free a history of VTE and/or anticoagulant use on enrolment. The CVD risk factors were updated during the follow-up period. Over a mean follow-up time of 15.5 years (237,375 person-years), 468 participants had VTE events. Adjusting for demographic variables and body mass index (BMI), current smokers were at greater risk [HR of 1.44 (95% CI: 1.12-1.86)] compared to non-smokers. There was a positive monotonic association between BMI and VTE risk. Individuals with a BMI ≥35 kg/m² had a HR for VTE of 3.09 (95%CI: 2.26-4.23) compared to those with normal BMI (

DOI10.1160/TH11-10-0726
Alternate JournalThromb Haemost
PubMed ID22782466
PubMed Central IDPMC3482827
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201000010C / HL / NHLBI NIH HHS / United States
HHSN268201100001I / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN2682011000010C / / PHS HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100002C / WH / WHI NIH HHS / United States
HHSN2682011000012C / / PHS HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
HHSN268201100002I / HL / NHLBI NIH HHS / United States
HHSN268201000012C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States
HHSN268201100001C / WH / WHI NIH HHS / United States
HHSN2682011000011C / / PHS HHS / United States