Pulse lineResearch With Heart Logo

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis.

TitleAdult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis.
Publication TypeJournal Article
Year of Publication2012
Corporate AuthorsEmerging Risk Factors Collaboration
JournalInt J Epidemiol
Volume41
Issue5
Pagination1419-33
Date Published2012 Oct
ISSN1464-3685
KeywordsAged, Aged, 80 and over, Alcohol Drinking, Body Height, Cardiovascular Diseases, Cause of Death, Female, Health Behavior, Humans, Lipids, Male, Middle Aged, Neoplasms, Smoking, Socioeconomic Factors, Vascular Diseases
Abstract

BACKGROUND: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.

METHODS: We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174374 deaths or major non-fatal vascular outcomes recorded among 1085949 people in 121 prospective studies.

RESULTS: For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.

CONCLUSION: Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.

DOI10.1093/ije/dys086
Alternate JournalInt J Epidemiol
PubMed ID22825588
PubMed Central IDPMC3465767
Grant ListUL1 TR000150 / TR / NCATS NIH HHS / United States
G0600705 / / Medical Research Council / United Kingdom
G19/35 / / Medical Research Council / United Kingdom
PG/09/002/26056 / / British Heart Foundation / United Kingdom
G0100222 / / Medical Research Council / United Kingdom
RG/08/014/24067 / / British Heart Foundation / United Kingdom
084674 / / Wellcome Trust / United Kingdom
G8802774 / / Medical Research Council / United Kingdom
G1000143 / / Medical Research Council / United Kingdom
RG/08/013/25942 / / British Heart Foundation / United Kingdom
G0902037 / / Medical Research Council / United Kingdom
MC_U137686857 / / Medical Research Council / United Kingdom
MC_U106179471 / / Medical Research Council / United Kingdom
UL1 TR000062 / TR / NCATS NIH HHS / United States
G0401527 / / Medical Research Council / United Kingdom
RG/08/014 / / British Heart Foundation / United Kingdom
RG/07/008/23674 / / British Heart Foundation / United Kingdom