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Marginal additive hazards model for case-cohort studies with multiple disease outcomes: an application to the Atherosclerosis Risk in Communities (ARIC) study.

TitleMarginal additive hazards model for case-cohort studies with multiple disease outcomes: an application to the Atherosclerosis Risk in Communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2013
AuthorsKang S, Cai J
Secondary AuthorsChambless L
JournalBiostatistics
Volume14
Issue1
Pagination28-41
Date Published2013 Jan
ISSN1468-4357
KeywordsAtherosclerosis, C-Reactive Protein, Case-Control Studies, Cohort Studies, Computer Simulation, Coronary Artery Disease, Coronary Disease, Humans, Proportional Hazards Models, Risk
Abstract

In the case-cohort studies conducted within the Atherosclerosis Risk in Communities (ARIC) study, it is of interest to assess and compare the effect of high-sensitivity C-reactive protein (hs-CRP) on the increased risks of incident coronary heart disease and incident ischemic stroke. Empirical cumulative hazards functions for different levels of hs-CRP reveal an additive structure for the risks for each disease outcome. Additionally, we are interested in estimating the difference in the risk for the different hs-CRP groups. Motivated by this, we consider fitting marginal additive hazards regression models for case-cohort studies with multiple disease outcomes. We consider a weighted estimating equations approach for the estimation of model parameters. The asymptotic properties of the proposed estimators are derived and their finite-sample properties are assessed via simulation studies. The proposed method is applied to analyze the ARIC Study.

DOI10.1093/biostatistics/kxs025
Alternate JournalBiostatistics
PubMed ID22826550
PubMed Central IDPMC3520500
Grant ListUL1 RR025747 / RR / NCRR NIH HHS / United States
R01-HL57444 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
R01 HL057444 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
P01CA142538 / CA / NCI NIH HHS / United States
P01 CA142538 / CA / NCI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States