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Genome-wide meta-analysis of common variant differences between men and women.

TitleGenome-wide meta-analysis of common variant differences between men and women.
Publication TypeJournal Article
Year of Publication2012
AuthorsBoraska V, Jerončić A, Colonna V, et al.
Secondary AuthorsZeggini E
Corporate AuthorsWellcome Trust Case Control Consortium
JournalHum Mol Genet
Volume21
Issue21
Pagination4805-15
Date Published2012 Nov 01
ISSN1460-2083
KeywordsEuropean Continental Ancestry Group, Female, Gene Frequency, Genome-Wide Association Study, Humans, Male, Models, Genetic, Polymorphism, Single Nucleotide, Sex Factors, Sex Ratio, Sexism
Abstract

The male-to-female sex ratio at birth is constant across world populations with an average of 1.06 (106 male to 100 female live births) for populations of European descent. The sex ratio is considered to be affected by numerous biological and environmental factors and to have a heritable component. The aim of this study was to investigate the presence of common allele modest effects at autosomal and chromosome X variants that could explain the observed sex ratio at birth. We conducted a large-scale genome-wide association scan (GWAS) meta-analysis across 51 studies, comprising overall 114 863 individuals (61 094 women and 53 769 men) of European ancestry and 2 623 828 common (minor allele frequency >0.05) single-nucleotide polymorphisms (SNPs). Allele frequencies were compared between men and women for directly-typed and imputed variants within each study. Forward-time simulations for unlinked, neutral, autosomal, common loci were performed under the demographic model for European populations with a fixed sex ratio and a random mating scheme to assess the probability of detecting significant allele frequency differences. We do not detect any genome-wide significant (P

DOI10.1093/hmg/dds304
Alternate JournalHum Mol Genet
PubMed ID22843499
PubMed Central IDPMC3471397
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
HL67466 / HL / NHLBI NIH HHS / United States
CZB/4/710 / / Chief Scientist Office / United Kingdom
G1001799 / / Medical Research Council / United Kingdom
HHSN268201100009I / HL / NHLBI NIH HHS / United States
R01 HL065234 / HL / NHLBI NIH HHS / United States
R01 AA007535 / AA / NIAAA NIH HHS / United States
MOP-82893 / / Canadian Institutes of Health Research / Canada
R56 DK062370 / DK / NIDDK NIH HHS / United States
R01 AA014041 / AA / NIAAA NIH HHS / United States
HL65234 / HL / NHLBI NIH HHS / United States
R01 MH081802 / MH / NIMH NIH HHS / United States
K05 AA017688 / AA / NIAAA NIH HHS / United States
R01 MH066206 / MH / NIMH NIH HHS / United States
R01HL59367 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
AA13320 / AA / NIAAA NIH HHS / United States
N.1-AG-1-2111 / AG / NIA NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
R01 MH062633 / MH / NIMH NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
R01 MD009164 / MD / NIMHD NIH HHS / United States
MC_U127561128 / / Medical Research Council / United Kingdom
R01 HL067466 / HL / NHLBI NIH HHS / United States
AA13321 / AA / NIAAA NIH HHS / United States
AA10248 / AA / NIAAA NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
P20 RR018787 / RR / NCRR NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
R01 AA013326 / AA / NIAAA NIH HHS / United States
G1000143 / / Medical Research Council / United Kingdom
MH66206 / MH / NIMH NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
N01-AG-1-2100 / AG / NIA NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
R01 DK062370 / DK / NIDDK NIH HHS / United States
076113 / / Wellcome Trust / United Kingdom
U01HG004402 / HG / NHGRI NIH HHS / United States
R01 AA013321 / AA / NIAAA NIH HHS / United States
MC_U106179471 / / Medical Research Council / United Kingdom
R01 MH059160 / MH / NIMH NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
/ / Intramural NIH HHS / United States
RR018787 / RR / NCRR NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
/ / Cancer Research UK / United Kingdom
095831 / / Wellcome Trust / United Kingdom
R01HL087641 / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
G0401527 / / Medical Research Council / United Kingdom
N.1-AG-1-1 / AG / NIA NIH HHS / United States
R01 LM010098 / LM / NLM NIH HHS / United States
MC_PC_U127561128 / / Medical Research Council / United Kingdom
098051 / / Wellcome Trust / United Kingdom
U24 MH068457 / MH / NIMH NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
DK062370 / DK / NIDDK NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
P30 DK020572 / DK / NIDDK NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
U24 MH068457-06 / MH / NIMH NIH HHS / United States
/ / Wellcome Trust / United Kingdom
092447/Z/10/Z / / Wellcome Trust / United Kingdom
AA14041 / AA / NIAAA NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
89061/Z/09/Z / / Wellcome Trust / United Kingdom
N01-AG-5-0002 / AG / NIA NIH HHS / United States
AA13326 / AA / NIAAA NIH HHS / United States
089062/Z/09/Z / / Wellcome Trust / United Kingdom
R01 AA013320 / AA / NIAAA NIH HHS / United States
R01HL086694 / HL / NHLBI NIH HHS / United States
LM010098 / LM / NLM NIH HHS / United States
MH081802 / MH / NIMH NIH HHS / United States