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Low hemoglobin A(1c) in nondiabetic adults: an elevated risk state?

TitleLow hemoglobin A(1c) in nondiabetic adults: an elevated risk state?
Publication TypeJournal Article
Year of Publication2012
AuthorsAggarwal V, Schneider ALC
Secondary AuthorsSelvin E
JournalDiabetes Care
Volume35
Issue10
Pagination2055-60
Date Published2012 Oct
ISSN1935-5548
KeywordsAdult, Cardiovascular Diseases, Cohort Studies, Female, Glycated Hemoglobin A, Hospitalization, Humans, Liver Diseases, Male, Middle Aged, Neoplasms, Proportional Hazards Models, Prospective Studies, Risk
Abstract

OBJECTIVE: To identify predictors of low hemoglobin A(1c) (HbA(1c)) (

RESEARCH DESIGN AND METHODS: Prospective cohort study of 13,288 participants in the Atherosclerosis Risk in Communities Study. Logistic regression was used to identify cross-sectional correlates of low HbA(1c), and Cox proportional hazards models were used to estimate the association of low HbA(1c) with cause-specific mortality.

RESULTS: Compared with participants with HbA(1c) in the normal range (5.0 to

CONCLUSIONS: No single cause of death appeared to drive the association between low HbA(1c) and total mortality. These results add to evidence that low HbA(1c) values may be a generalized marker of mortality risk in the general population.

DOI10.2337/dc11-2531
Alternate JournalDiabetes Care
PubMed ID22855733
PubMed Central IDPMC3447844
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
K01-DK-076595 / DK / NIDDK NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
R01-DK-089174 / DK / NIDDK NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
T32-DK-062707 / DK / NIDDK NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R21-DK-080294 / DK / NIDDK NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
K01 DK076595 / DK / NIDDK NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
T32 DK062707 / DK / NIDDK NIH HHS / United States
R21 DK080294 / DK / NIDDK NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States