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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

TitleLarge-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
Publication TypeJournal Article
Year of Publication2012
AuthorsScott RA, Lagou V, Welch RP, et al.
Secondary AuthorsBarroso I
Corporate AuthorsDIAbetes Genetics Replication and Meta-analysis(DIAGRAM) Consortium
JournalNat Genet
Volume44
Issue9
Pagination991-1005
Date Published2012 Sep
ISSN1546-1718
KeywordsAdult, Animals, Blood Glucose, Fasting, Female, Gene Frequency, Genome-Wide Association Study, Humans, Insulin, Male, Metabolic Networks and Pathways, Mice, Osmolar Concentration, Quantitative Trait Loci
Abstract

Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q

DOI10.1038/ng.2385
Alternate JournalNat Genet
PubMed ID22885924
PubMed Central IDPMC3433394
Grant ListM01-RR00425 / RR / NCRR NIH HHS / United States
076467 / WT_ / Wellcome Trust / United Kingdom
R01 DK078616 / DK / NIDDK NIH HHS / United States
AG04563 / AG / NIA NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
DK078150 / DK / NIDDK NIH HHS / United States
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R01-HL-088215 / HL / NHLBI NIH HHS / United States
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083948 / WT_ / Wellcome Trust / United Kingdom
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CZB/4/710 / / Chief Scientist Office / United Kingdom
G9521010 / / Medical Research Council / United Kingdom
CZB/4/672 / / Chief Scientist Office / United Kingdom
098017 / / Wellcome Trust / United Kingdom
R01 MH063706 / MH / NIMH NIH HHS / United States
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P30 ES010126 / ES / NIEHS NIH HHS / United States
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G19/35 / / Medical Research Council / United Kingdom
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