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Anemia and the onset of gout in a population-based cohort of adults: Atherosclerosis Risk in Communities study.

TitleAnemia and the onset of gout in a population-based cohort of adults: Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2012
AuthorsMcAdams-Demarco MA, Maynard JW, Coresh JJ
Secondary AuthorsBaer AN
JournalArthritis Res Ther
Volume14
Issue4
PaginationR193
Date Published2012 Aug 20
ISSN1478-6362
KeywordsAnemia, Atherosclerosis, Cohort Studies, Female, Follow-Up Studies, Gout, Humans, Male, Middle Aged, Population Surveillance, Prospective Studies, Residence Characteristics, Risk Factors
Abstract

INTRODUCTION: There is a growing prevalence of gout in the US and worldwide. Gout is a recognized risk factor for cardiovascular disease (CVD). It is unclear whether other risk factors for CVD are also associated with increased risk of gout. Anemia is one such CVD risk factor. No studies have evaluated the relationship between anemia and gout. We tested whether anemia was associated with incident gout independent of comorbid conditions in Atherosclerosis Risk in the Communities.

METHODS: This population-based cohort recruited 15,792 individuals in 1987 to 1989 from four US communities and contained nine years of follow-up. Anemia was defined as hemoglobin

RESULTS: Among the 10,791 participants, 10% had anemia at baseline. There were 271 cases of incident gout. Patients with anemia had a two-fold increased risk of developing gout over nine years (HR = 2.01, 95% CI: 1.46, 2.76). Anemia was associated with incident gout independent of known gout risk factors, confounders and clinical risk factors (HR = 1.73, 95% CI: 1.24, 2.41). This association persisted after additionally adjusting for serum urate level (HR = 1.83, 95% CI: 1.30, 2.57).

CONCLUSION: We identified anemia as a novel risk factor for gout. Anemia was associated with an approximately two-fold increased risk of gout-independent kidney function and serum urate. These findings suggest that anemia is a risk factor for gout on par with other chronic conditions such as obesity and diabetes. The biological mechanism linking anemia to gout remains unclear.

DOI10.1186/ar4026
Alternate JournalArthritis Res Ther
PubMed ID22906142
PubMed Central IDPMC3580590
Grant ListHHSN268201100005C / / PHS HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States