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Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.

TitleGenome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
Publication TypeJournal Article
Year of Publication2012
AuthorsHuang J, Sabater-Lleal M, Asselbergs FW, Tregouet D, Shin S-Y, Ding J, Baumert J, Oudot-Mellakh T, Folkersen L, Johnson AD, Smith NL, Williams SM, Ikram MA, Kleber ME, Becker DM, Truong V, Mychaleckyj JC, Tang W, Yang Q, Sennblad B, Moore JH, Williams FMK, Dehghan A, Silbernagel G, Schrijvers EMC, Smith S, Karakas M, Tofler GH, Silveira A, Navis GJ, Lohman K, Chen M-H, Peters A, Goel A, Hopewell JC, Chambers JC, Saleheen D, Lundmark P, Psaty BM, Strawbridge RJ, Boehm BO, Carter AM, Meisinger C, Peden JF, Bis JC, McKnight B, Öhrvik J, Taylor K, Franzosi MGrazia, Seedorf U, Collins R, Franco-Cereceda A, Syvänen A-C, Goodall AH, Yanek LR, Cushman M, Müller-Nurasyid M, Folsom AR, Basu S, Matijevic N, van Gilst WH, Kooner JS, Hofman A, Danesh J, Clarke R, Meigs JB, Kathiresan S, Reilly MP, Klopp N, Harris TB, Winkelmann BR, Grant PJ, Hillege HL, Watkins H, Spector TD, Becker LC, Tracy RP, März W, Uitterlinden AG, Eriksson P, Cambien F, Morange P-E, Koenig W, Soranzo N, van der Harst P, Liu Y, O'Donnell CJ
Secondary AuthorsHamsten A
Corporate AuthorsDIAGRAM Consortium, CARDIoGRAM Consortium, C4D Consortium, Cardiogenics Consortium
JournalBlood
Volume120
Issue24
Pagination4873-81
Date Published2012 Dec 06
ISSN1528-0020
KeywordsAdaptor Proteins, Signal Transducing, ARNTL Transcription Factors, ATPases Associated with Diverse Cellular Activities, Cell Line, Cell Line, Tumor, Cohort Studies, Coronary Artery Disease, Diabetes Mellitus, Type 2, Gene Expression Profiling, Gene Expression Regulation, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, LIM Domain Proteins, Meta-Analysis as Topic, Monocytes, Mucin-3, Plasminogen Activator Inhibitor 1, Polymorphism, Single Nucleotide, PPAR gamma, Proteasome Endopeptidase Complex, RNA Interference, Transcription Factors
Abstract

We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, followed by replication analysis of genome-wide significant (P

DOI10.1182/blood-2012-06-436188
Alternate JournalBlood
PubMed ID22990020
PubMed Central IDPMC3520624
Grant ListN02-HL-6-4278 / HL / NHLBI NIH HHS / United States
HL67466 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
P20 GM103534 / GM / NIGMS NIH HHS / United States
N01-HC-95162 / HC / NHLBI NIH HHS / United States
R01-HL-086694 / HL / NHLBI NIH HHS / United States
R01-HL59367 / HL / NHLBI NIH HHS / United States
HL65234 / HL / NHLBI NIH HHS / United States
N01-HC-85085 / HC / NHLBI NIH HHS / United States
UL1-RR-025005 / RR / NCRR NIH HHS / United States
T32 GM080178 / GM / NIGMS NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-85081 / HC / NHLBI NIH HHS / United States
HL105756 / HL / NHLBI NIH HHS / United States
RR-024156 / RR / NCRR NIH HHS / United States
R01-HL-087641 / HL / NHLBI NIH HHS / United States
R01 HL095603 / HL / NHLBI NIH HHS / United States
N01AG62101 / AG / NIA NIH HHS / United States
N01-HC-95163 / HC / NHLBI NIH HHS / United States
G0700931 / / Medical Research Council / United Kingdom
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-95168 / HC / NHLBI NIH HHS / United States
RG/08/014/24067 / / British Heart Foundation / United Kingdom
AG-15928 / AG / NIA NIH HHS / United States
/ / Biotechnology and Biological Sciences Research Council / United Kingdom
N01-HC-95159 / HC / NHLBI NIH HHS / United States
1R01AG032098-01A1 / AG / NIA NIH HHS / United States
/ / Department of Health / United Kingdom
AG-20098 / AG / NIA NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
N01-HC-95165 / HC / NHLBI NIH HHS / United States
HL087652 / HL / NHLBI NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
MC_U137686857 / / Medical Research Council / United Kingdom
R01HL071252 / HL / NHLBI NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States
R01HL071205 / HL / NHLBI NIH HHS / United States
AG-027058 / AG / NIA NIH HHS / United States
N01-HC-85082 / HC / NHLBI NIH HHS / United States
R01-HL-59367 / HL / NHLBI NIH HHS / United States
/ / Intramural NIH HHS / United States
N01-HC-35129 / HC / NHLBI NIH HHS / United States
RR018787 / RR / NCRR NIH HHS / United States
N01 HC-55222 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-95169 / HC / NHLBI NIH HHS / United States
N01-HC-95164 / HC / NHLBI NIH HHS / United States
R01 LM010098 / LM / NLM NIH HHS / United States
K24 DK080140 / DK / NIDDK NIH HHS / United States
N01-HC-85083 / HC / NHLBI NIH HHS / United States
090532 / / Wellcome Trust / United Kingdom
N01-HC-75150 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-85080 / HC / NHLBI NIH HHS / United States
N01-HC-95160 / HC / NHLBI NIH HHS / United States
N01 HC-15103 / HC / NHLBI NIH HHS / United States
U01 HL072518 / HL / NHLBI NIH HHS / United States
R01 HL59684 / HL / NHLBI NIH HHS / United States
DK063491 / DK / NIDDK NIH HHS / United States
N01-HC-45133 / HC / NHLBI NIH HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
N01-HC-95161 / HC / NHLBI NIH HHS / United States
N01AG62103 / AG / NIA NIH HHS / United States
HHSN268201200036C / / PHS HHS / United States
HHSN268200782096C / / PHS HHS / United States
HL080295 / HL / NHLBI NIH HHS / United States
N01AG62106 / AG / NIA NIH HHS / United States
R01HL071259 / HL / NHLBI NIH HHS / United States
N01-HC-85239 / HC / NHLBI NIH HHS / United States
AG-023629 / AG / NIA NIH HHS / United States
R01HL071251 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-95166 / HC / NHLBI NIH HHS / United States
U01-HG-004402 / HG / NHGRI NIH HHS / United States
1U01 HL072518 / HL / NHLBI NIH HHS / United States
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M01 RR00052 / RR / NCRR NIH HHS / United States
R01HL071051 / HL / NHLBI NIH HHS / United States
R01HL071250 / HL / NHLBI NIH HHS / United States
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N01-HC-95167 / HC / NHLBI NIH HHS / United States
LM010098 / LM / NLM NIH HHS / United States