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Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.

TitleGene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.
Publication TypeJournal Article
Year of Publication2013
AuthorsGuo Y, Lanktree MB, Taylor KC, Hakonarson H, Lange LA
Secondary AuthorsKeating BJ
Corporate AuthorsIBC 50K SNP array BMI Consortium
JournalHum Mol Genet
Volume22
Issue1
Pagination184-201
Date Published2013 Jan 01
ISSN1460-2083
KeywordsBody Mass Index, Cohort Studies, Ethnic Groups, Humans, Polymorphism, Single Nucleotide
Abstract

Recent genetic association studies have made progress in uncovering components of the genetic architecture of the body mass index (BMI). We used the ITMAT-Broad-Candidate Gene Association Resource (CARe) (IBC) array comprising up to 49 320 single nucleotide polymorphisms (SNPs) across ~2100 metabolic and cardiovascular-related loci to genotype up to 108 912 individuals of European ancestry (EA), African-Americans, Hispanics and East Asians, from 46 studies, to provide additional insight into SNPs underpinning BMI. We used a five-phase study design: Phase I focused on meta-analysis of EA studies providing individual level genotype data; Phase II performed a replication of cohorts providing summary level EA data; Phase III meta-analyzed results from the first two phases; associated SNPs from Phase III were used for replication in Phase IV; finally in Phase V, a multi-ethnic meta-analysis of all samples from four ethnicities was performed. At an array-wide significance (P

DOI10.1093/hmg/dds396
Alternate JournalHum Mol Genet
PubMed ID23001569
PubMed Central IDPMC3522401
Grant ListG9521010 / / Medical Research Council / United Kingdom
PG/09/022/26739 / / British Heart Foundation / United Kingdom
G0600705 / / Medical Research Council / United Kingdom
G19/35 / / Medical Research Council / United Kingdom
G0100222 / / Medical Research Council / United Kingdom
R37 AG011099 / AG / NIA NIH HHS / United States
R01 AG021917 / AG / NIA NIH HHS / United States
G8802774 / / Medical Research Council / United Kingdom
G0902037 / / Medical Research Council / United Kingdom
HHSN268200960009C) / / PHS HHS / United States
R01 AG016592 / AG / NIA NIH HHS / United States
MC_U137686857 / / Medical Research Council / United Kingdom
U01 DK057136 / DK / NIDDK NIH HHS / United States
P01 HL088117 / HL / NHLBI NIH HHS / United States
K23 DK097307 / DK / NIDDK NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada
P30 DK072488 / DK / NIDDK NIH HHS / United States
K24 HL084034 / HL / NHLBI NIH HHS / United States
090532 / / Wellcome Trust / United Kingdom
R01 HL111614 / HL / NHLBI NIH HHS / United States
P50 HL081011 / HL / NHLBI NIH HHS / United States
U01 DK057131 / DK / NIDDK NIH HHS / United States
R01 HL091099 / HL / NHLBI NIH HHS / United States
R01 HL088577 / HL / NHLBI NIH HHS / United States
MR/K006584/1 / / Medical Research Council / United Kingdom
MR/K013351/1 / / Medical Research Council / United Kingdom
K07 CA136969 / CA / NCI NIH HHS / United States
L30 HL097857 / HL / NHLBI NIH HHS / United States
P30 DK017047 / DK / NIDDK NIH HHS / United States
RG/07/008/23674 / / British Heart Foundation / United Kingdom
RG/10/12/28456 / / British Heart Foundation / United Kingdom