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Discovery and fine mapping of serum protein loci through transethnic meta-analysis.

TitleDiscovery and fine mapping of serum protein loci through transethnic meta-analysis.
Publication TypeJournal Article
Year of Publication2012
AuthorsFranceschini N, van Rooij FJA, Prins BP, et al.
Corporate AuthorsLifeLines Cohort Study
JournalAm J Hum Genet
Volume91
Issue4
Pagination744-53
Date Published2012 Oct 05
ISSN1537-6605
KeywordsAdult, Aged, Alleles, Animals, Asians, Blood Proteins, Chromosome Mapping, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Male, Mice, Middle Aged, Protein Biosynthesis, Proteolysis, Ribosomes, Serum Albumin, Whites
Abstract

Many disorders are associated with altered serum protein concentrations, including malnutrition, cancer, and cardiovascular, kidney, and inflammatory diseases. Although these protein concentrations are highly heritable, relatively little is known about their underlying genetic determinants. Through transethnic meta-analysis of European-ancestry and Japanese genome-wide association studies, we identified six loci at genome-wide significance (p

DOI10.1016/j.ajhg.2012.08.021
Alternate JournalAm J Hum Genet
PubMed ID23022100
PubMed Central IDPMC3484648
Grant List098017 / / Wellcome Trust / United Kingdom
R01HL089651 / HL / NHLBI NIH HHS / United States
MC_U127561128 / / Medical Research Council / United Kingdom
U01HG004803 / HG / NHGRI NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
R01 HL089651 / HL / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
U01 HG004803 / HG / NHGRI NIH HHS / United States
G0700704 / / Medical Research Council / United Kingdom
BB/F019394/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom
AHA0675001N / / PHS HHS / United States
WT064890 / WT_ / Wellcome Trust / United Kingdom
WT081682 / WT_ / Wellcome Trust / United Kingdom
CZB/4/710 / / Chief Scientist Office / United Kingdom
090532 / / Wellcome Trust / United Kingdom
MC_PC_U127561128 / / Medical Research Council / United Kingdom