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Hypertension and the risk of incident gout in a population-based study: the atherosclerosis risk in communities cohort.

TitleHypertension and the risk of incident gout in a population-based study: the atherosclerosis risk in communities cohort.
Publication TypeJournal Article
Year of Publication2012
AuthorsMcAdams-Demarco MA, Maynard JW, Baer AN
Secondary AuthorsCoresh JJ
JournalJ Clin Hypertens (Greenwich)
Volume14
Issue10
Pagination675-9
Date Published2012 Oct
ISSN1751-7176
KeywordsAfrican Americans, Arteriosclerosis, Cohort Studies, Community Networks, Confidence Intervals, European Continental Ancestry Group, Female, Gout, Humans, Hypertension, Incidence, Male, Middle Aged, Prospective Studies, Qualitative Research, Risk Assessment, Statistics as Topic, Time Factors, United States
Abstract

The authors quantified the impact of hypertension on gout incidence in middle-aged white and African American men and women. The Atherosclerosis Risk in Communities Study (ARIC) was a prospective population-based cohort that recruited patients between 1987 and 1989 from 4 US communities. Using a time-dependent Cox proportional hazards model, the authors estimated the adjusted hazard ratio (HR) of incident gout by time-varying hypertension and tested for mediation by serum urate level. There were 10,872 participants among whom 45% had hypertension during follow-up; 43% were men and 21% were African American. Over 9 years, 274 (2.5%) participants developed gout (1.8% of women and 3.5% of men). The unadjusted HR of incident gout was approximately 3 times (HR, 2.87; 95% confidence interval [CI], 2.24-3.78) greater for those with hypertension. Adjusting for confounders resulted in an attenuated but still significant association between hypertension and gout (HR, 2.00; 95% CI, 1.54-2.61). Adjustment for serum urate level further attenuated but did not abrogate the association (HR, 1.36, 95% CI, 1.04-1.79). There was no evidence of effect modification by sex (P=.35), race (P=.99), or obesity at baseline (P=.82). Hypertension was independently associated with increased gout risk in middle-aged African American and white adults. Serum urate level may be a partial intermediate on the pathway between hypertension and gout.

DOI10.1111/j.1751-7176.2012.00674.x
Alternate JournalJ Clin Hypertens (Greenwich)
PubMed ID23031144
PubMed Central IDPMC3464949
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
T32 HL007024 / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
5T32HL007024 / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States