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Hyperglycemia and arterial stiffness: the Atherosclerosis Risk in the Communities study.

TitleHyperglycemia and arterial stiffness: the Atherosclerosis Risk in the Communities study.
Publication TypeJournal Article
Year of Publication2012
AuthorsRubin J, Nambi V, Chambless LE, Steffes MW, Juraschek SP, Coresh JJ, Sharrett ARichey
Secondary AuthorsSelvin E
JournalAtherosclerosis
Volume225
Issue1
Pagination246-51
Date Published2012 Nov
ISSN1879-1484
KeywordsAtherosclerosis, Carotid Artery, Common, Carotid Intima-Media Thickness, Elastic Modulus, Female, Glycated Hemoglobin A, Humans, Hyperglycemia, Male, Middle Aged, Vascular Stiffness
Abstract

OBJECTIVES: Hyperglycemia has been associated with an increased risk of cardiovascular morbidity and mortality. Although numerous studies have demonstrated that hyperglycemia is associated with the atherosis component of atherosclerosis, limited studies have addressed the independent role of hyperglycemia in the pathophysiology of sclerotic vascular disease. We hypothesized that hyperglycemia, as assessed by hemoglobin A1c (HbA1c), would be independently associated two common indices of arterial stiffness (pressure-strain elastic modulus (Ep) and Young's elastic modulus (YEM)).

METHODS: We examined the cross-sectional association between HbA1c and arterial stiffness using B-mode ultrasound examination of the carotid artery in 9050 participants from the community-based Atherosclerosis Risk in Communities (ARIC) study. We used multivariable linear and logistic regression models to characterize the association between HbA1c and increased Ep and YEM.

RESULTS: Higher values of HbA1c were associated in a graded fashion with increased arterial stiffness (P-trendĀ 

CONCLUSION: Elevated HbA1c is associated with measures of increased arterial stiffness, even after accounting for arterial wall thickness. This is consistent with the hypothesis that hyperglycemia contributes to arterial stiffness beyond its effects on atherosis and suggests that hyperglycemia is associated with altered material within the arterial wall.

DOI10.1016/j.atherosclerosis.2012.09.003
Alternate JournalAtherosclerosis
PubMed ID23031361
PubMed Central IDPMC3936879
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
R21HL092344-01A1 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
T32 HL007024 / HL / NHLBI NIH HHS / United States
K01 DK076595 / DK / NIDDK NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
R01 DK076770 / DK / NIDDK NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
R21 DK080294 / DK / NIDDK NIH HHS / United States