Pulse lineResearch With Heart Logo

Association between physical activity and risk of stroke subtypes: the atherosclerosis risk in communities study.

TitleAssociation between physical activity and risk of stroke subtypes: the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2013
AuthorsAutenrieth CS, Evenson KR, Yatsuya H, Shahar E, Baggett C
Secondary AuthorsRosamond WD
JournalNeuroepidemiology
Volume40
Issue2
Pagination109-16
Date Published2013
ISSN1423-0208
KeywordsAfrican Americans, Cohort Studies, Female, Humans, Incidence, Intracranial Arteriosclerosis, Leisure Activities, Male, Middle Aged, Motor Activity, Prospective Studies, Risk Assessment, Sports, Stroke, United States
Abstract

BACKGROUND: The relationship between stroke subtypes and physical activity is unclear.

METHODS: Using data from 13,069 men and women aged 45-64 years who participated in the Atherosclerosis Risk in Communities Study, physical activity was assessed by self-report using the Baecke questionnaire at baseline (1987-1989). The American Heart Association's ideal cardiovascular health guidelines served as a basis for the calculation of three physical activity categories: poor, intermediate, and ideal. Stroke and its subtypes were ascertained from physician review of medical records. Multivariable adjusted hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox regression models.

RESULTS: During a median follow-up of 18.8 years, a total of 648 incident ischemic strokes occurred. Significant inverse associations were found between physical activity categories and total, total ischemic, and nonlacunar stroke in adjusted models (age, sex, race-center, education, cigarette-years). Compared with poor physical activity, the adjusted HR (95% CI) for ideal physical activity were 0.78 (0.62-0.97) for total, 0.76 (0.59-0.96) for total ischemic, 0.85 (0.51-1.40) for lacunar, 0.77 (0.47-1.27) for cardioembolic, and 0.71 (0.51-0.99) for nonlacunar stroke. Additional adjustments for waist-to-hip ratio, systolic blood pressure, antihypertensive medication, diabetes, left ventricular hypertrophy and laboratory parameters attenuated the HR. Further sex- and race-specific analyses revealed that the association was predominantly observed among males and among African-Americans.

CONCLUSION: These data suggest a tendency toward a reduced risk of total, total ischemic, and nonlacunar stroke with higher levels of physical activity.

DOI10.1159/000342151
Alternate JournalNeuroepidemiology
PubMed ID23095721
PubMed Central IDPMC3641888
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN262801100010C / / PHS HHS / United States
HHSN262801100009C / / PHS HHS / United States
HHSN262801100011C / / PHS HHS / United States
HHSN262801100012C / / PHS HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN262801100008C / / PHS HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN262801100007C / / PHS HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268200900020C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
HHSN262801100006C / / PHS HHS / United States