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Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study.

TitleTransferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study.
Publication TypeJournal Article
Year of Publication2013
AuthorsC Y Ng M, Saxena R, Li J, Palmer ND, Dimitrov L, Xu J, Rasmussen-Torvik LJ, Zmuda JM, Siscovick DS, Patel SR, Crook ED, Sims M, Chen Y-DI, Bertoni AG, Li M, Grant SFA, Dupuis J, Meigs JB, Psaty BM, Pankow JS, Langefeld CD, Freedman BI, Rotter JI, Wilson JG
Secondary AuthorsBowden DW
JournalDiabetes
Volume62
Issue3
Pagination965-76
Date Published2013 Mar
ISSN1939-327X
KeywordsAfrican Americans, Aged, Case-Control Studies, Cohort Studies, Diabetes Mellitus, Type 2, Female, Genetic Loci, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Prospective Studies, Transcription Factor 7-Like 2 Protein, United States
Abstract

Type 2 diabetes (T2D) disproportionally affects African Americans (AfA) but, to date, genetic variants identified from genome-wide association studies (GWAS) are primarily from European and Asian populations. We examined the single nucleotide polymorphism (SNP) and locus transferability of 40 reported T2D loci in six AfA GWAS consisting of 2,806 T2D case subjects with or without end-stage renal disease and 4,265 control subjects from the Candidate Gene Association Resource Plus Study. Our results revealed that seven index SNPs at the TCF7L2, KLF14, KCNQ1, ADCY5, CDKAL1, JAZF1, and GCKR loci were significantly associated with T2D (P

DOI10.2337/db12-0266
Alternate JournalDiabetes
PubMed ID23193183
PubMed Central IDPMC3581206
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HHSC268200782096C / / PHS HHS / United States
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UL1 RR025005 / RR / NCRR NIH HHS / United States
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HHSN268201100011C / HL / NHLBI NIH HHS / United States
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