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Loci influencing blood pressure identified using a cardiovascular gene-centric array.

TitleLoci influencing blood pressure identified using a cardiovascular gene-centric array.
Publication TypeJournal Article
Year of Publication2013
AuthorsGanesh SK, Tragante V, Guo W, et al.
Secondary AuthorsAsselbergs FW
Corporate AuthorsCARDIOGRAM, METASTROKE, LifeLines Cohort Study
JournalHum Mol Genet
Volume22
Issue8
Pagination1663-78
Date Published2013 Apr 15
ISSN1460-2083
KeywordsAdult, Aged, Blood Pressure, Cardiovascular Diseases, Chromosome Mapping, Cohort Studies, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide
Abstract

Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped ∼50 000 single-nucleotide polymorphisms (SNPs) that capture variation in ∼2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P

DOI10.1093/hmg/dds555
Alternate JournalHum Mol Genet
PubMed ID23303523
PubMed Central IDPMC3657476
Grant ListG9521010 / MRC_ / Medical Research Council / United Kingdom
R01 DK071224 / DK / NIDDK NIH HHS / United States
U01 GM074492 / GM / NIGMS NIH HHS / United States
R01 HL088120 / HL / NHLBI NIH HHS / United States
R01 AG016592 / AG / NIA NIH HHS / United States
P01 HL088117 / HL / NHLBI NIH HHS / United States
K24 HL084034 / HL / NHLBI NIH HHS / United States
R01 CA047988 / CA / NCI NIH HHS / United States
MR/K006584/1 / MRC_ / Medical Research Council / United Kingdom
G0600237 / MRC_ / Medical Research Council / United Kingdom
U01 HG006830 / HG / NHGRI NIH HHS / United States
090532 / WT_ / Wellcome Trust / United Kingdom
R01 HL111614 / HL / NHLBI NIH HHS / United States
N01HC65226 / HL / NHLBI NIH HHS / United States