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The identification of prediabetes condition with ARIC algorithm predicts long-term CV events in patients with erectile dysfunction.

TitleThe identification of prediabetes condition with ARIC algorithm predicts long-term CV events in patients with erectile dysfunction.
Publication TypeJournal Article
Year of Publication2013
AuthorsCorona G, Rastrelli G, Silverii A, Monami M, Sforza A, Forti G, Mannucci E
Secondary AuthorsMaggi M
JournalJ Sex Med
Volume10
Issue4
Pagination1114-23
Date Published2013 Apr
ISSN1743-6109
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Algorithms, Cardiovascular Diseases, Cross-Sectional Studies, Erectile Dysfunction, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Prediabetic State, Predictive Value of Tests, Retrospective Studies, Risk Assessment, ROC Curve, Young Adult
Abstract

INTRODUCTION: The Atherosclerosis Risk in Communities (ARIC) algorithm is one of the most efficient instruments for the prediction of incident type 2 diabetes. Recently, it has been shown to predict another relevant cardiovascular (CV) risk factor, such as chronic kidney disease.

AIM: To verify whether, in patients with erectile dysfunction (ED), the use of ARIC diabetes risk score might improve the efficacy in predicting major CV events of other CV risk algorithms specifically developed for the assessment of CV risk.

METHODS: A consecutive series of 2,437 men (mean age 52.5 ± 12.9 years) attending our outpatient clinic for sexual dysfunction was retrospectively studied. A subset of this sample (N = 1,687) was enrolled in a longitudinal study (mean follow-up of 4.3 ± 2.6 years).

MAIN OUTCOME MEASURES: The assessment of metabolic risk was evaluated with the ARIC algorithm. The assessment of CV risk was evaluated using the Progetto Cuore risk engine.

RESULTS: In the cross-sectional study, ARIC score was inversely related with testosterone levels, sexual functioning, and penile blood flow. When longitudinal sample was analyzed, higher baseline ARIC score significantly predicted major adverse cardiovascular event (MACE) even when subjects with diabetes mellitus at baseline were excluded from the analysis (hazard ratio = 1.522 [1.086-2.135]; P = 0.015 for trend). In addition, among subjects classified as "low risk" (CV risk

CONCLUSIONS: In patients with ED, identifying prediabetes, even with algorithms, predicts long-term CV events.

DOI10.1111/jsm.12066
Alternate JournalJ Sex Med
PubMed ID23347470