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Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study.

TitleLactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2013
AuthorsJuraschek SP, Shantha GPalamaner, Chu AY, Miller ER, Guallar E, Hoogeveen RC, Ballantyne CM, Brancati FL, Schmidt M I, Pankow JS
Secondary AuthorsYoung HJ
JournalPLoS One
Volume8
Issue1
Paginatione55113
Date Published2013
ISSN1932-6203
KeywordsAtherosclerosis, Case-Control Studies, Cohort Studies, Diabetes Mellitus, Type 2, Female, Humans, Incidence, Kaplan-Meier Estimate, Lactic Acid, Longitudinal Studies, Male, Middle Aged, Residence Characteristics, Risk
Abstract

BACKGROUND: Oxidative capacity is decreased in type 2 diabetes. Whether decreased oxidative capacity is a cause or consequence of diabetes is unknown. Our purpose is to evaluate whether lactate, a marker of oxidative capacity, is associated with incident diabetes.

METHODS AND FINDINGS: We conducted a case-cohort study in the Atherosclerosis Risk in Communities (ARIC) study at year 9 of follow-up. We evaluated lactate's association with diabetes risk factors at baseline and estimated the hazard ratio for incident diabetes by quartiles of plasma lactate in 544 incident diabetic cases and 533 non-cases. Plasma lactate showed a graded positive relationship with fasting glucose and insulin (P

CONCLUSIONS: Lactate, an indicator of oxidative capacity, predicts incident diabetes independent of many other risk factors and is strongly related to markers of insulin resistance. Future studies should evaluate the temporal relationship between elevated lactate and impaired fasting glucose and insulin resistance.

DOI10.1371/journal.pone.0055113
Alternate JournalPLoS One
PubMed ID23383072
PubMed Central IDPMC3559502
Grant ListN01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
T32 HL007575 / HL / NHLBI NIH HHS / United States
P30 DK079637 / DK / NIDDK NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
5P60DK079637-04 / DK / NIDDK NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
T32HL007024 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States