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Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.

TitleGenome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
Publication TypeJournal Article
Year of Publication2013
AuthorsChen Z, Tang H, Qayyum R, Schick UM, Nalls MA, Handsaker R, Li J, Lu Y, Yanek LR, Keating B, Meng Y, van Rooij FJA, Okada Y, Kubo M, Rasmussen-Torvik L, Keller MF, Lange L, Evans M, Bottinger EP, Linderman MD, Ruderfer DM, Hakonarson H, Papanicolaou G, Zonderman AB, Gottesman O, Thomson C, Ziv E, Singleton AB, Loos RJF, Sleiman PMA, Ganesh S, McCarroll S, Becker DM, Wilson JG, Lettre G
Secondary AuthorsReiner AP
Corporate AuthorsBioBank Japan Project, CHARGE Consortium
JournalHum Mol Genet
Volume22
Issue12
Pagination2529-38
Date Published2013 Jun 15
ISSN1460-2083
KeywordsAdolescent, Adult, African Americans, alpha-Globins, Child, Chromosomes, Human, Pair 16, Cohort Studies, Erythrocyte Count, Erythrocyte Indices, Erythrocytes, European Continental Ancestry Group, Female, Genome-Wide Association Study, Hemoglobins, Humans, Male, Polymorphism, Single Nucleotide, Young Adult
Abstract

Laboratory red blood cell (RBC) measurements are clinically important, heritable and differ among ethnic groups. To identify genetic variants that contribute to RBC phenotypes in African Americans (AAs), we conducted a genome-wide association study in up to ~16 500 AAs. The alpha-globin locus on chromosome 16pter [lead SNP rs13335629 in ITFG3 gene; P

DOI10.1093/hmg/ddt087
Alternate JournalHum Mol Genet
PubMed ID23446634
PubMed Central IDPMC3658166
Grant ListN01 AG062101 / AG / NIA NIH HHS / United States
RR03655 / RR / NCRR NIH HHS / United States
N01HC95095 / HL / NHLBI NIH HHS / United States
N01-HC-95100 / HC / NHLBI NIH HHS / United States
44221 / / PHS HHS / United States
N01WH22110 / WH / WHI NIH HHS / United States
N01HC55020 / HL / NHLBI NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
R01HL86694 / HL / NHLBI NIH HHS / United States
32105-6 / / PHS HHS / United States
N01-HC-45205 / HC / NHLBI NIH HHS / United States
N01-AG-821336 / AG / NIA NIH HHS / United States
Z01 AG000513 / / Intramural NIH HHS / United States
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N01-HC-05187 / HC / NHLBI NIH HHS / United States
N01-HC-55017 / HC / NHLBI NIH HHS / United States
R01 HL087698 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
R01 NR008153 / NR / NINR NIH HHS / United States
UL1 TR000150 / TR / NCATS NIH HHS / United States
R01HL59367 / HL / NHLBI NIH HHS / United States
N01-HC-48047 / HC / NHLBI NIH HHS / United States
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R01 MD009164 / MD / NIMHD NIH HHS / United States
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42107-26 / / PHS HHS / United States
32115 / / PHS HHS / United States
2009-149 / / PHS HHS / United States
N01-HC-45204 / HC / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
263 MD 9164 13 / MD / NIMHD NIH HHS / United States
1R01AG032098-01A1 / AG / NIA NIH HHS / United States
N01-HC-95095 / HC / NHLBI NIH HHS / United States
K23 HL105897 / HL / NHLBI NIH HHS / United States
M01-RR000052 / RR / NCRR NIH HHS / United States
N01 AG062106 / AG / NIA NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
32100-2 / / PHS HHS / United States
24152 / / PHS HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
R01 AG032098 / AG / NIA NIH HHS / United States
N01-HC-48050 / HC / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
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U01 HG006830 / HG / NHGRI NIH HHS / United States