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Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

TitleExploring the genetic basis of chronic periodontitis: a genome-wide association study.
Publication TypeJournal Article
Year of Publication2013
AuthorsDivaris K, Monda KL, North KE, Olshan AF, Reynolds LM, Hsueh W-C, Lange EM, Moss K, Barros SP, Weyant RJ, Liu Y, Newman AB, Beck JD
Secondary AuthorsOffenbacher S
JournalHum Mol Genet
Volume22
Issue11
Pagination2312-24
Date Published2013 Jun 01
ISSN1460-2083
KeywordsAdult, Age Factors, Aged, Alleles, Body Composition, Chronic Periodontitis, Cohort Studies, Female, Gene Frequency, Genetic Loci, Genome-Wide Association Study, Genotype, Humans, Male, Meta-Analysis as Topic, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Risk Factors, Signal Transduction
Abstract

Chronic periodontitis (CP) is a common oral disease that confers substantial systemic inflammatory and microbial burden and is a major cause of tooth loss. Here, we present the results of a genome-wide association study of CP that was carried out in a cohort of 4504 European Americans (EA) participating in the Atherosclerosis Risk in Communities (ARIC) Study (mean age-62 years, moderate CP-43% and severe CP-17%). We detected no genome-wide significant association signals for CP; however, we found suggestive evidence of association (P

DOI10.1093/hmg/ddt065
Alternate JournalHum Mol Genet
PubMed ID23459936
PubMed Central IDPMC3652417
Grant ListUL1RR025005 / RR / NCRR NIH HHS / United States
R01DE021418 / DE / NIDCR NIH HHS / United States
P30 ES010126 / ES / NIEHS NIH HHS / United States
R01HL59367 / HL / NHLBI NIH HHS / United States
HSN268201100012C / / PHS HHS / United States
HHSN268201100005C / / PHS HHS / United States
N01AG62101 / AG / NIA NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
1R01AG032098-01A1 / AG / NIA NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
HHSN268201100010C / / PHS HHS / United States
R01 ES014843 / ES / NIEHS NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
N01AG6210 / AG / NIA NIH HHS / United States
R01HL087641 / HL / NHLBI NIH HHS / United States
R01DE11551 / DE / NIDCR NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
N01AG62103 / AG / NIA NIH HHS / United States
HHSN268200782096C / / PHS HHS / United States
N01AG62106 / AG / NIA NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States
P30ES010126 / ES / NIEHS NIH HHS / United States
R01HL74104 / HL / NHLBI NIH HHS / United States
R01HL086694 / HL / NHLBI NIH HHS / United States