| Title | Exploring the genetic basis of chronic periodontitis: a genome-wide association study. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Divaris K, Monda KL, North KE, Olshan AF, Reynolds LM, Hsueh W-C, Lange EM, Moss K, Barros SP, Weyant RJ, Liu Y, Newman AB, Beck JD, Offenbacher S |
| Journal | Hum Mol Genet |
| Volume | 22 |
| Issue | 11 |
| Pagination | 2312-24 |
| Date Published | 2013 Jun 01 |
| ISSN | 1460-2083 |
| Keywords | Adult, Age Factors, Aged, Alleles, Body Composition, Chronic Periodontitis, Cohort Studies, Female, Gene Frequency, Genetic Loci, Genome-Wide Association Study, Genotype, Humans, Male, Meta-Analysis as Topic, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Risk Factors, Signal Transduction |
| Abstract | Chronic periodontitis (CP) is a common oral disease that confers substantial systemic inflammatory and microbial burden and is a major cause of tooth loss. Here, we present the results of a genome-wide association study of CP that was carried out in a cohort of 4504 European Americans (EA) participating in the Atherosclerosis Risk in Communities (ARIC) Study (mean age-62 years, moderate CP-43% and severe CP-17%). We detected no genome-wide significant association signals for CP; however, we found suggestive evidence of association (P |
| DOI | 10.1093/hmg/ddt065 |
| Alternate Journal | Hum Mol Genet |
| PubMed ID | 23459936 |
| PubMed Central ID | PMC3652417 |
| Grant List | P30 ES010126 / ES / NIEHS NIH HHS / United States R01HL59367 / HL / NHLBI NIH HHS / United States HSN268201100012C / / PHS HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States N01AG62101 / AG / NIA NIH HHS / United States 1R01AG032098-01A1 / AG / NIA NIH HHS / United States HHSN268200625226C / / PHS HHS / United States R01 ES014843 / ES / NIEHS NIH HHS / United States U01HG004402 / HG / NHGRI NIH HHS / United States R01DE11551 / DE / NIDCR NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States N01AG62103 / AG / NIA NIH HHS / United States P30ES010126 / ES / NIEHS NIH HHS / United States R01HL086694 / HL / NHLBI NIH HHS / United States UL1RR025005 / RR / NCRR NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States R01DE021418 / DE / NIDCR NIH HHS / United States N01AG6210 / AG / NIA NIH HHS / United States R01HL087641 / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States HHSN268200782096C / HG / NHGRI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States N01AG62106 / AG / NIA NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States R01HL74104 / HL / NHLBI NIH HHS / United States |