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Genetic predisposition to higher blood pressure increases coronary artery disease risk.

TitleGenetic predisposition to higher blood pressure increases coronary artery disease risk.
Publication TypeJournal Article
Year of Publication2013
AuthorsLieb W, Jansen H, Loley C, Pencina MJ, Nelson CP, Newton-Cheh C, Kathiresan S, Reilly MP, Assimes TL, Boerwinkle E, Hall AS, Hengstenberg C, Laaksonen R, McPherson R, Thorsteinsdottir U, Ziegler A, Peters A, Thompson JR, König IR, Erdmann J, Samani NJ, Vasan RS
Secondary AuthorsSchunkert H
Corporate AuthorsCARDIOGRAM
JournalHypertension
Volume61
Issue5
Pagination995-1001
Date Published2013 May
ISSN1524-4563
KeywordsAdult, Aged, Alleles, Blood Pressure, Case-Control Studies, Coronary Artery Disease, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Hypertension, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors
Abstract

Hypertension is a risk factor for coronary artery disease. Recent genome-wide association studies have identified 30 genetic variants associated with higher blood pressure at genome-wide significance (P1 for coronary artery disease, a proportion much higher than expected by chance (P=4 × 10(-5)). The average relative coronary artery disease risk increase per each of the multiple blood pressure-raising alleles observed in the consortium was 3.0% for systolic blood pressure-associated polymorphisms (95% confidence interval, 1.8%-4.3%) and 2.9% for diastolic blood pressure-associated polymorphisms (95% confidence interval, 1.7%-4.1%). In substudies, individuals carrying most systolic blood pressure- and diastolic blood pressure-related risk alleles (top quintile of a genetic risk score distribution) had 70% (95% confidence interval, 50%-94%) and 59% (95% confidence interval, 40%-81%) higher odds of having coronary artery disease, respectively, as compared with individuals in the bottom quintile. In conclusion, most blood pressure-associated polymorphisms also confer an increased risk for coronary artery disease. These findings are consistent with a causal relationship of increasing blood pressure to coronary artery disease. Genetic variants primarily affecting blood pressure contribute to the genetic basis of coronary artery disease.

DOI10.1161/HYPERTENSIONAHA.111.00275
Alternate JournalHypertension
PubMed ID23478099
PubMed Central IDPMC3855241
Grant ListN01‐HC‐55022 / HC / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
CIHR #MOP77682 / / Canadian Institutes of Health Research / Canada
R01 HL087676 / HL / NHLBI NIH HHS / United States
/ / British Heart Foundation / United Kingdom
R01HL089650‐02 / HL / NHLBI NIH HHS / United States
N01 HC025195 / HC / NHLBI NIH HHS / United States
/ / Medical Research Council / United Kingdom
P01 HL098055 / HL / NHLBI NIH HHS / United States
P01HL076491‐06 / HL / NHLBI NIH HHS / United States
CIHR #MOP172605 / / Canadian Institutes of Health Research / Canada
N01‐HC‐55019 / HC / NHLBI NIH HHS / United States
R01DK080732 / DK / NIDDK NIH HHS / United States
N01‐HC‐55018 / HC / NHLBI NIH HHS / United States
/ / Intramural NIH HHS / United States
/ / Cancer Research UK / United Kingdom
P01HL087018 / HL / NHLBI NIH HHS / United States
CIHR #MOP‐‐82810 / / Canadian Institutes of Health Research / Canada
N01‐AG‐12100 / AG / NIA NIH HHS / United States
N01‐HC‐55015 / HC / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
N01‐HC‐55021 / HC / NHLBI NIH HHS / United States
HL087647 / HL / NHLBI NIH HHS / United States
N01‐HC‐55020 / HC / NHLBI NIH HHS / United States
1R01HL103931‐01 / HL / NHLBI NIH HHS / United States
/ / Wellcome Trust / United Kingdom
N01‐HC‐55016 / HC / NHLBI NIH HHS / United States