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Association of blood lactate with carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.

TitleAssociation of blood lactate with carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.
Publication TypeJournal Article
Year of Publication2013
AuthorsShantha GPalamaner, Wasserman B, Astor BC, Coresh JJ, Brancati F, Sharrett ARichey
Secondary AuthorsYoung HJ
JournalAtherosclerosis
Volume228
Issue1
Pagination249-55
Date Published2013 May
ISSN1879-1484
KeywordsAged, Biomarkers, Carotid Artery Diseases, Cholesterol, HDL, Female, Gadolinium, Humans, Insulin Resistance, Lactic Acid, Magnetic Resonance Angiography, Male, Residence Characteristics, Risk Factors, Triglycerides
Abstract

OBJECTIVES: Cardiovascular risk factors such as aging, smoking, and insulin resistance may lead to atherosclerosis through various mechanisms of which their association with mitochondrial dysfunction may be one of them. In order to examine this hypothesis, we assessed the association between elevated blood lactate, a marker of mitochondrial dysfunction, and carotid atherosclerosis.

METHODS: From a total of 2066 participants from the Atherosclerosis Risk In Communities Carotid MRI study, 1496 were included for this analysis. Wall Thickness and Lipid core presence were measured using gadolinium-enhanced MRI. Blood lactate was categorized into quartiles (Q1: 9.2 mg/dl).

RESULTS: Of the 1496 study participants, 763 (51%) were females, 296 (19.8%) African American, 539 (36%) obese and 308 (20.6%) had diabetes. There was a strong and graded association between lactate and wall thickness [Q1: 1.08 mm (95% CI: 1.01 mm-1.15 mm), Q2: 1.33 mm (95% CI: 1.19 mm-1.47 mm), Q3: 1.44 (95% CI: 1.34 mm-1.54 mm) and Q4: 1.62 (95% CI: 1.53 mm-1.71 mm); p for trend

CONCLUSIONS: Blood lactate is associated with carotid atherosclerosis. Attenuation of the association with adjustment for triglyceride/HDL ratio, a marker of insulin resistance, suggests that lactate's association with carotid atherosclerosis may be related to insulin resistance.

DOI10.1016/j.atherosclerosis.2013.02.014
Alternate JournalAtherosclerosis
PubMed ID23510829
PubMed Central IDPMC3657708
Grant ListNIH/NHLBI RO1DK085458 / DK / NIDDK NIH HHS / United States
NIH/NHLBI T32HL007024 / / PHS HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
R01 DK085458 / DK / NIDDK NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States