|Title||Association of blood lactate with carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Shantha GPalamaner, Wasserman B, Astor BC, Coresh JJ, Brancati F, Sharrett ARichey|
|Secondary Authors||Young HJ|
|Date Published||2013 May|
|Keywords||Aged, Biomarkers, Carotid Artery Diseases, Cholesterol, HDL, Female, Gadolinium, Humans, Insulin Resistance, Lactic Acid, Magnetic Resonance Angiography, Male, Residence Characteristics, Risk Factors, Triglycerides|
OBJECTIVES: Cardiovascular risk factors such as aging, smoking, and insulin resistance may lead to atherosclerosis through various mechanisms of which their association with mitochondrial dysfunction may be one of them. In order to examine this hypothesis, we assessed the association between elevated blood lactate, a marker of mitochondrial dysfunction, and carotid atherosclerosis.
METHODS: From a total of 2066 participants from the Atherosclerosis Risk In Communities Carotid MRI study, 1496 were included for this analysis. Wall Thickness and Lipid core presence were measured using gadolinium-enhanced MRI. Blood lactate was categorized into quartiles (Q1: 9.2 mg/dl).
RESULTS: Of the 1496 study participants, 763 (51%) were females, 296 (19.8%) African American, 539 (36%) obese and 308 (20.6%) had diabetes. There was a strong and graded association between lactate and wall thickness [Q1: 1.08 mm (95% CI: 1.01 mm-1.15 mm), Q2: 1.33 mm (95% CI: 1.19 mm-1.47 mm), Q3: 1.44 (95% CI: 1.34 mm-1.54 mm) and Q4: 1.62 (95% CI: 1.53 mm-1.71 mm); p for trend
CONCLUSIONS: Blood lactate is associated with carotid atherosclerosis. Attenuation of the association with adjustment for triglyceride/HDL ratio, a marker of insulin resistance, suggests that lactate's association with carotid atherosclerosis may be related to insulin resistance.
|PubMed Central ID||PMC3657708|
|Grant List||NIH/NHLBI RO1DK085458 / DK / NIDDK NIH HHS / United States |
NIH/NHLBI T32HL007024 / / PHS HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
R01 DK085458 / DK / NIDDK NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States