Pulse lineResearch With Heart Logo

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

TitleA meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Publication TypeJournal Article
Year of Publication2013
AuthorsMonda KL, Chen GK, Taylor KC, et al.
Secondary AuthorsHaiman CA
Corporate AuthorsNABEC Consortium, UKBEC Consortium, BioBank Japan Project, AGEN Consortium
JournalNat Genet
Volume45
Issue6
Pagination690-6
Date Published2013 Jun
ISSN1546-1718
KeywordsAfrican Americans, Body Mass Index, Case-Control Studies, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Obesity, Polymorphism, Single Nucleotide
Abstract

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.

DOI10.1038/ng.2608
Alternate JournalNat Genet
PubMed ID23583978
PubMed Central IDPMC3694490
Grant ListU01-HL054512 / HL / NHLBI NIH HHS / United States
ES011126 / ES / NIEHS NIH HHS / United States
U01 HL054472 / HL / NHLBI NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
CA54281 / CA / NCI NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
R01 HL071025 / HL / NHLBI NIH HHS / United States
R01-HL-088215 / HL / NHLBI NIH HHS / United States
UL1 RR033176 / RR / NCRR NIH HHS / United States
R01 AI061774 / AI / NIAID NIH HHS / United States
R01 HL053353 / HL / NHLBI NIH HHS / United States
U01 HL054471 / HL / NHLBI NIH HHS / United States
U19 CA148127 / CA / NCI NIH HHS / United States
CA73629 / CA / NCI NIH HHS / United States
N01-HC-45205 / HC / NHLBI NIH HHS / United States
K23 DK080145 / DK / NIDDK NIH HHS / United States
P20 GM103534 / GM / NIGMS NIH HHS / United States
N01-HC-95162 / HC / NHLBI NIH HHS / United States
UL1RR033176 / RR / NCRR NIH HHS / United States
CA77305 / CA / NCI NIH HHS / United States
UL1TR000124 / TR / NCATS NIH HHS / United States
RC2 CA148085 / CA / NCI NIH HHS / United States
Z01-AG000513 / AG / NIA NIH HHS / United States
P30 CA016672 / CA / NCI NIH HHS / United States
ES007784 / ES / NIEHS NIH HHS / United States
R01 HG003054 / HG / NHGRI NIH HHS / United States
N01-HC-05187 / HC / NHLBI NIH HHS / United States
N01 HC048050 / HC / NHLBI NIH HHS / United States
N01 HC095170 / HC / NHLBI NIH HHS / United States
CA88164 / CA / NCI NIH HHS / United States
R01-HL-071252 / HL / NHLBI NIH HHS / United States
R01 ES006717 / ES / NIEHS NIH HHS / United States
S06GM008016-380111 / GM / NIGMS NIH HHS / United States
R01 HL071251 / HL / NHLBI NIH HHS / United States
R01 HL087698 / HL / NHLBI NIH HHS / United States
R01 HL101161 / HL / NHLBI NIH HHS / United States
N01 HC048047 / HC / NHLBI NIH HHS / United States
R01 CA089085 / CA / NCI NIH HHS / United States
R01 HL046380 / HL / NHLBI NIH HHS / United States
CA127298 / CA / NCI NIH HHS / United States
R01-HL086718 / HL / NHLBI NIH HHS / United States
CA092579 / CA / NCI NIH HHS / United States
R01-HL-071258 / HL / NHLBI NIH HHS / United States
UL1 TR000150 / TR / NCATS NIH HHS / United States
R01 CA133996 / CA / NCI NIH HHS / United States
U10 CA037429 / CA / NCI NIH HHS / United States
R01 CA142996 / CA / NCI NIH HHS / United States
HHSC268200782096C / / PHS HHS / United States
N01-HC-85085 / HC / NHLBI NIH HHS / United States
R01HL59367 / HL / NHLBI NIH HHS / United States
U01 CA69417 / CA / NCI NIH HHS / United States
R01 HL071259 / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
UL1-RR-025005 / RR / NCRR NIH HHS / United States
P50 CA125183 / CA / NCI NIH HHS / United States
CA1326792 / CA / NCI NIH HHS / United States
R01 AG015928 / AG / NIA NIH HHS / United States
N01 AG062101 / AG / NIA NIH HHS / United States
S06GM008016-320107 / GM / NIGMS NIH HHS / United States
K23 AR052364 / AR / NIAMS NIH HHS / United States
HHSN271201100004C / / PHS HHS / United States
N01 HC048048 / HC / NHLBI NIH HHS / United States
U01 HG004790 / HG / NHGRI NIH HHS / United States
N01-HC-48047 / HC / NHLBI NIH HHS / United States
R01-DK-8925601 / DK / NIDDK NIH HHS / United States
R01 CA098663 / CA / NCI NIH HHS / United States
R01 CA141712 / CA / NCI NIH HHS / United States
R01 CA121197 / CA / NCI NIH HHS / United States
R01 HL071252 / HL / NHLBI NIH HHS / United States
HHSN268201100001C / / PHS HHS / United States
Z01HG200362 / HG / NHGRI NIH HHS / United States
M01RR00080 / RR / NCRR NIH HHS / United States
N01 HC075150 / HC / NHLBI NIH HHS / United States
N01-HC-85081 / HC / NHLBI NIH HHS / United States
N01HG25487 / ES / NIEHS NIH HHS / United States
HHSN26820110009C / / PHS HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
R01 HL087660 / HL / NHLBI NIH HHS / United States
N01-HC-95163 / HC / NHLBI NIH HHS / United States
R01-HL-071250 / HL / NHLBI NIH HHS / United States
N01 HC015103 / HC / NHLBI NIH HHS / United States
U01 CA127298 / CA / NCI NIH HHS / United States
R01 HL085251 / HL / NHLBI NIH HHS / United States
N01-HC-95168 / HC / NHLBI NIH HHS / United States
U01 HL054509 / HL / NHLBI NIH HHS / United States
UL1-RR-024156 / RR / NCRR NIH HHS / United States
R01 CA092447 / CA / NCI NIH HHS / United States
R01 CA073629 / CA / NCI NIH HHS / United States
R01DK075787 / DK / NIDDK NIH HHS / United States
N01-HC-45204 / HC / NHLBI NIH HHS / United States
R01 HL071250 / HL / NHLBI NIH HHS / United States
N01 HC065226 / HC / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
R01 CA127219 / CA / NCI NIH HHS / United States
UL1 RR024156 / RR / NCRR NIH HHS / United States
R01 AI079139 / AI / NIAID NIH HHS / United States
R01 HL074166 / HL / NHLBI NIH HHS / United States
N02 HL64278 / HL / NHLBI NIH HHS / United States
P30 CA016086 / CA / NCI NIH HHS / United States
R37 HL045508 / HL / NHLBI NIH HHS / United States
N01-HC-95159 / HC / NHLBI NIH HHS / United States
N01 HC045205 / HC / NHLBI NIH HHS / United States
CA056678 / CA / NCI NIH HHS / United States
N01 HC095172 / HC / NHLBI NIH HHS / United States
1R01AG032098-01A1 / AG / NIA NIH HHS / United States
R01 HL087652 / HL / NHLBI NIH HHS / United States
AG-20098 / AG / NIA NIH HHS / United States
N01-HC-95095 / HC / NHLBI NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
U01 HG004424 / HG / NHGRI NIH HHS / United States
N01-HC-95165 / HC / NHLBI NIH HHS / United States
R01 DK075787 / DK / NIDDK NIH HHS / United States
HL54515 / HL / NHLBI NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
N01 AG062106 / AG / NIA NIH HHS / United States
R01-HL-071251 / HL / NHLBI NIH HHS / United States
N01HC55222 / HL / NHLBI NIH HHS / United States
R01-DK075787 / DK / NIDDK NIH HHS / United States
ES10126 / ES / NIEHS NIH HHS / United States
R01 DK075681 / DK / NIDDK NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States
N01 HC095171 / HC / NHLBI NIH HHS / United States
P50 CA058223 / CA / NCI NIH HHS / United States
R01 CA100374 / CA / NCI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
HG004726 / HG / NHGRI NIH HHS / United States
CA68578 / CA / NCI NIH HHS / United States
R01 CA056678 / CA / NCI NIH HHS / United States
N01-HC-48050 / HC / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
N01 HC095095 / HC / NHLBI NIH HHS / United States
R01 DK087914 / DK / NIDDK NIH HHS / United States
HHSN268201100003C / / PHS HHS / United States
AG-027058 / AG / NIA NIH HHS / United States
CA63464 / CA / NCI NIH HHS / United States
HHSN268201100004C / / PHS HHS / United States
HHSN26820110006C / / PHS HHS / United States
HL 46380 / HL / NHLBI NIH HHS / United States
N01-HC-85082 / HC / NHLBI NIH HHS / United States
CA082664 / CA / NCI NIH HHS / United States
R01 HL071051 / HL / NHLBI NIH HHS / United States
R01 CA058420 / CA / NCI NIH HHS / United States
P30 CA060553 / CA / NCI NIH HHS / United States
N01-HC-35129 / HC / NHLBI NIH HHS / United States
R01 CA077305 / CA / NCI NIH HHS / United States
R01 DK066358 / DK / NIDDK NIH HHS / United States
HHSN26820110007C / / PHS HHS / United States
N01 HC-55222 / HC / NHLBI NIH HHS / United States
R01 DK084350 / DK / NIDDK NIH HHS / United States
P20 MD006899 / MD / NIMHD NIH HHS / United States
CA164973 / CA / NCI NIH HHS / United States
R01 CA055769 / CA / NCI NIH HHS / United States
R01 HD056465 / HD / NICHD NIH HHS / United States
HHSN26820110008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
R01-HL-071259 / HL / NHLBI NIH HHS / United States
R01HL087641 / HL / NHLBI NIH HHS / United States
CA148085 / CA / NCI NIH HHS / United States
UM1 CA164974 / CA / NCI NIH HHS / United States
Z01 HG200362-01 / / Intramural NIH HHS / United States
R01 HL55673 / HL / NHLBI NIH HHS / United States
N01-HC-95169 / HC / NHLBI NIH HHS / United States
HL087660 / HL / NHLBI NIH HHS / United States
HL54496 / HL / NHLBI NIH HHS / United States
RC1 HL100245 / HL / NHLBI NIH HHS / United States
N01 AG062103 / AG / NIA NIH HHS / United States
N01-HC-95164 / HC / NHLBI NIH HHS / United States
U01 NS041588 / NS / NINDS NIH HHS / United States
R01 CA063464 / CA / NCI NIH HHS / United States
UL1 TR000439 / TR / NCATS NIH HHS / United States
R01 LM010098 / LM / NLM NIH HHS / United States
R01-HL-071205 / HL / NHLBI NIH HHS / United States
N01 HC045204 / HC / NHLBI NIH HHS / United States
RFA CA-06-503 / CA / NCI NIH HHS / United States
HHSN26820110005C / / PHS HHS / United States
N01-HC-48049 / HC / NHLBI NIH HHS / United States
N01 HC005187 / HC / NHLBI NIH HHS / United States
R01 CA141716 / CA / NCI NIH HHS / United States
N01-HC-85083 / HC / NHLBI NIH HHS / United States
N01-HC-75150 / HC / NHLBI NIH HHS / United States
CA100374 / CA / NCI NIH HHS / United States
N01 HC045134 / HC / NHLBI NIH HHS / United States
KL2 TR000446 / TR / NCATS NIH HHS / United States
N01 HC095169 / HC / NHLBI NIH HHS / United States
R01-HL-087700 / HL / NHLBI NIH HHS / United States
N01-HC-85080 / HC / NHLBI NIH HHS / United States
N01-HC-95160 / HC / NHLBI NIH HHS / United States
R01 CA082664 / CA / NCI NIH HHS / United States
R01 HL080295 / HL / NHLBI NIH HHS / United States
R01-DK-075681 / DK / NIDDK NIH HHS / United States
U01 HL072518 / HL / NHLBI NIH HHS / United States
R01 CA054281 / CA / NCI NIH HHS / United States
N01-HC-95171 / HC / NHLBI NIH HHS / United States
HL54473 / HL / NHLBI NIH HHS / United States
U01 HG005157 / HG / NHGRI NIH HHS / United States
R01 HL088215 / HL / NHLBI NIH HHS / United States
R01 CA088164 / CA / NCI NIH HHS / United States
R01-HL053353 / HL / NHLBI NIH HHS / United States
R01 HL059684 / HL / NHLBI NIH HHS / United States
CA140388 / CA / NCI NIH HHS / United States
HL100245 / HL / NHLBI NIH HHS / United States
M01 RR07122 / RR / NCRR NIH HHS / United States
R01 HL079055 / HL / NHLBI NIH HHS / United States
N01-HC-95172 / HC / NHLBI NIH HHS / United States
R01 HL086718 / HL / NHLBI NIH HHS / United States
UL1 TR000055 / TR / NCATS NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
CA092447 / CA / NCI NIH HHS / United States
HHSN268201100046C / / PHS HHS / United States
1UL1RR024975-01 / RR / NCRR NIH HHS / United States
R01 HL071205 / HL / NHLBI NIH HHS / United States
R01 DK064695 / DK / NIDDK NIH HHS / United States
DK063491 / DK / NIDDK NIH HHS / United States
N01-HC-45133 / HC / NHLBI NIH HHS / United States
R01 DK053591 / DK / NIDDK NIH HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
N01-HC-95161 / HC / NHLBI NIH HHS / United States
CA68485 / CA / NCI NIH HHS / United States
UL1 RR024975 / RR / NCRR NIH HHS / United States
HHSN268201200036C / / PHS HHS / United States
N01-HC-95100 / HC / NHLBI NIH HHS / United States
R01-HL-071051 / HL / NHLBI NIH HHS / United States
HHSN268200782096C / / PHS HHS / United States
K07 CA136969 / CA / NCI NIH HHS / United States
R01-HL074166 / HL / NHLBI NIH HHS / United States
R01 ES011126 / ES / NIEHS NIH HHS / United States
CA58223 / CA / NCI NIH HHS / United States
T32 DK007734 / DK / NIDDK NIH HHS / United States
HL54495 / HL / NHLBI NIH HHS / United States
N01-HC-85239 / HC / NHLBI NIH HHS / United States
R01 CA114379 / CA / NCI NIH HHS / United States
N01-HC-48048 / HC / NHLBI NIH HHS / United States
AG-023629 / AG / NIA NIH HHS / United States
N01 HC085079 / HC / NHLBI NIH HHS / United States
R01 CA111646 / CA / NCI NIH HHS / United States
R01 HL117078 / HL / NHLBI NIH HHS / United States
R24 HD050924 / HD / NICHD NIH HHS / United States
N02-HL-64278 / HL / NHLBI NIH HHS / United States
N01-HC-95166 / HC / NHLBI NIH HHS / United States
R01 AG023629 / AG / NIA NIH HHS / United States
U01 HL054512 / HL / NHLBI NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
2M01RR010284 / RR / NCRR NIH HHS / United States
R01 CA092579 / CA / NCI NIH HHS / United States
U01 HG005152 / HG / NHGRI NIH HHS / United States
R01 HL058625 / HL / NHLBI NIH HHS / United States
HHSN268201100002C / / PHS HHS / United States
R01 AG027058 / AG / NIA NIH HHS / United States
R01 HL087700 / HL / NHLBI NIH HHS / United States
UM1 CA182883 / CA / NCI NIH HHS / United States
N01-HC-95170 / HC / NHLBI NIH HHS / United States
SC1 HL095100 / HL / NHLBI NIH HHS / United States
U01 HL054495 / HL / NHLBI NIH HHS / United States
R01 HL071258 / HL / NHLBI NIH HHS / United States
S06GM08016 / GM / NIGMS NIH HHS / United States
HHSN26800625226C / / PHS HHS / United States
N01HG25487 / HG / NHGRI NIH HHS / United States
HL101161 / HL / NHLBI NIH HHS / United States
HL54471 / HL / NHLBI NIH HHS / United States
HL54509 / HL / NHLBI NIH HHS / United States
R37-HL045508 / HL / NHLBI NIH HHS / United States
R01 HL055673 / HL / NHLBI NIH HHS / United States
N01-HD-3-3175 / HD / NICHD NIH HHS / United States
N01-HC-85084 / HC / NHLBI NIH HHS / United States
U01 HL054473 / HL / NHLBI NIH HHS / United States
P60 AR062755 / AR / NIAMS NIH HHS / United States
N01 HC095159 / HC / NHLBI NIH HHS / United States
N01-HC-95167 / HC / NHLBI NIH HHS / United States
R01HL086694 / HL / NHLBI NIH HHS / United States
HL54472 / HL / NHLBI NIH HHS / United States
N01-HC-65226 / HC / NHLBI NIH HHS / United States
U01 HG004726 / HG / NHGRI NIH HHS / United States
U01 HG006830 / HG / NHGRI NIH HHS / United States
R01 CA100598 / CA / NCI NIH HHS / United States
R01-HG003054 / HG / NHGRI NIH HHS / United States