Title | Genome-wide association study of age at menarche in African-American women. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Demerath EW, Liu C-T, Franceschini N, Chen G, Palmer JR, Smith EN, Chen CTL, Ambrosone CB, Arnold AM, Bandera EV, Berenson GS, Bernstein L, Britton A, Cappola AR, Carlson CS, Chanock SJ, Chen W, Chen Z, Deming SL, Elks CE, Evans MK, Gajdos Z, Henderson BE, Hu JJ, Ingles S, John EM, Kerr KF, Kolonel LN, Le Marchand L, Lu X, Millikan RC, Musani SK, Nock NL, North K, Nyante S, Press MF, Rodriquez-Gil JL, Ruiz-Narvaez EA, Schork NJ, Srinivasan SR, Woods NF, Zheng W, Ziegler RG, Zonderman A, Heiss G, B Windham G, Wellons M, Murray SS, Nalls M, Pastinen T, Rajkovic A, Hirschhorn J, L Cupples A, Kooperberg C, Murabito JM, Haiman CA |
Journal | Hum Mol Genet |
Volume | 22 |
Issue | 16 |
Pagination | 3329-46 |
Date Published | 2013 Aug 15 |
ISSN | 1460-2083 |
Keywords | Adolescent, African Americans, Case-Control Studies, Child, Diabetes Mellitus, Type 2, Female, Genetic Loci, Genetic Variation, Genome-Wide Association Study, Humans, Linear Models, Membrane Glycoproteins, Membrane Proteins, Menarche, Nuclear Receptor Subfamily 1, Group F, Member 1, Obesity, Polymorphism, Single Nucleotide, Risk Factors, Whites, Young Adult |
Abstract | African-American (AA) women have earlier menarche on average than women of European ancestry (EA), and earlier menarche is a risk factor for obesity and type 2 diabetes among other chronic diseases. Identification of common genetic variants associated with age at menarche has a potential value in pointing to the genetic pathways underlying chronic disease risk, yet comprehensive genome-wide studies of age at menarche are lacking for AA women. In this study, we tested the genome-wide association of self-reported age at menarche with common single-nucleotide polymorphisms (SNPs) in a total of 18 089 AA women in 15 studies using an additive genetic linear regression model, adjusting for year of birth and population stratification, followed by inverse-variance weighted meta-analysis (Stage 1). Top meta-analysis results were then tested in an independent sample of 2850 women (Stage 2). First, while no SNP passed the pre-specified P |
DOI | 10.1093/hmg/ddt181 |
Alternate Journal | Hum Mol Genet |
PubMed ID | 23599027 |
PubMed Central ID | PMC3723312 |
Grant List | U01-CA69417 / CA / NCI NIH HHS / United States HHSN 268201100002C / / PHS HHS / United States M01-RR-00080 / RR / NCRR NIH HHS / United States UM1 CA164974 / CA / NCI NIH HHS / United States UL1RR025005 / RR / NCRR NIH HHS / United States HHSN268201100001C / WH / WHI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States N01-HC-45205 / HC / NHLBI NIH HHS / United States R01-CA73629 / CA / NCI NIH HHS / United States P30 ES010126 / ES / NIEHS NIH HHS / United States Z01-AG000513 / AG / NIA NIH HHS / United States N01-HC-05187 / HC / NHLBI NIH HHS / United States DAMD17-96-6071 / / PHS HHS / United States R01HL59367 / HL / NHLBI NIH HHS / United States RFA CA-95-011 / CA / NCI NIH HHS / United States UM1 CA164920 / CA / NCI NIH HHS / United States N01-HC-48047 / HC / NHLBI NIH HHS / United States R01 CA098663 / CA / NCI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States R01-CA63464 / CA / NCI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States N01-HC-45204 / HC / NHLBI NIH HHS / United States HHSN271201100004C / AG / NIA NIH HHS / United States R01-CA100598 / CA / NCI NIH HHS / United States N01-HC-95095 / HC / NHLBI NIH HHS / United States HHSN268200625226C / / PHS HHS / United States R01 AG016592 / AG / NIA NIH HHS / United States 1U54RR025204-01 / RR / NCRR NIH HHS / United States HHSN268200900055C / HL / NHLBI NIH HHS / United States P50 CA058223 / CA / NCI NIH HHS / United States P50-CA58223 / CA / NCI NIH HHS / United States U01HG004402 / HG / NHGRI NIH HHS / United States N01-HC-48050 / HC / NHLBI NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States R01 CA058420 / CA / NCI NIH HHS / United States HHSN268201100004C / WH / WHI NIH HHS / United States N01-HC-45134 / HC / NHLBI NIH HHS / United States 5215810-550000234 / / PHS HHS / United States R01HL087641 / HL / NHLBI NIH HHS / United States HHSN268201100012C / HL / NHLBI NIH HHS / United States N01-HC-48049 / HC / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States N01-HC-95171 / HC / NHLBI NIH HHS / United States HHSN268201100046C / HL / NHLBI NIH HHS / United States HHSN268201100003C / WH / WHI NIH HHS / United States UL1RR025774 / RR / NCRR NIH HHS / United States HD-062783 / HD / NICHD NIH HHS / United States N01-HC-95172 / HC / NHLBI NIH HHS / United States AG-16592 / AG / NIA NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States R01-CA77305 / CA / NCI NIH HHS / United States R01-CA100374 / CA / NCI NIH HHS / United States N01-HC-95100 / HC / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States R21AG032598 / AG / NIA NIH HHS / United States N01-HC-48048 / HC / NHLBI NIH HHS / United States N02-HL-64278 / HL / NHLBI NIH HHS / United States R01-HL4638 / HL / NHLBI NIH HHS / United States HD-061437 / HD / NICHD NIH HHS / United States N01-HC-95170 / HC / NHLBI NIH HHS / United States K23-HL-87114 / HL / NHLBI NIH HHS / United States R37-CA54281 / CA / NCI NIH HHS / United States N01-HD-3-3175 / HD / NICHD NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States P30-ES10126 / ES / NIEHS NIH HHS / United States R01HL086694 / HL / NHLBI NIH HHS / United States N01-HC-65226 / HC / NHLBI NIH HHS / United States |