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The shared allelic architecture of adiponectin levels and coronary artery disease.

TitleThe shared allelic architecture of adiponectin levels and coronary artery disease.
Publication TypeJournal Article
Year of Publication2013
AuthorsDastani Z, Johnson T, Kronenberg F, Nelson CP, Assimes TL, März W, J Richards B
Corporate AuthorsCARDIoGRAM Consortium, ADIPOGen Consortium
Date Published2013 Jul
KeywordsAdiponectin, Adiposity, Alleles, Atherosclerosis, Coronary Artery Disease, Databases, Genetic, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Prevalence, Risk Factors

OBJECTIVE: A large body of epidemiologic data strongly suggests an association between excess adiposity and coronary artery disease (CAD). Low adiponectin levels, a hormone secreted only from adipocytes, have been associated with an increased risk of CAD in observational studies. However, these associations cannot clarify whether this relationship is causal or due to a shared set of causal factors or even confounding. Genome-wide association studies have identified common variants that influence adiponectin levels, providing valuable tools to examine the genetic relationship between adiponectin and CAD.

METHODS: Using 145 genome wide significant SNPs for adiponectin from the ADIPOGen consortium (n = 49,891), we tested whether adiponectin-decreasing alleles influenced risk of CAD in the CARDIoGRAM consortium (n = 85,274).

RESULTS: In single-SNP analysis, 5 variants among 145 SNPs were associated with increased risk of CAD after correcting for multiple testing (P

CONCLUSION: These findings demonstrate that adiponectin levels and CAD have a shared allelic architecture and provide rationale to undertake a Mendelian randomization studies to understand if this relationship is causal.

Alternate JournalAtherosclerosis
PubMed ID23664276
PubMed Central IDPMC6139652
Grant List090532 / / Wellcome Trust / United Kingdom
098498 / / Wellcome Trust / United Kingdom
Z99 AG999999 / / Intramural NIH HHS / United States
/ CAPMC / CIHR / Canada