|Title||The shared allelic architecture of adiponectin levels and coronary artery disease.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Dastani Z, Johnson T, Kronenberg F, Nelson CP, Assimes TL, März W|
|Secondary Authors||J Richards B|
|Corporate Authors||CARDIoGRAM Consortium, ADIPOGen Consortium|
|Date Published||2013 Jul|
|Keywords||Adiponectin, Adiposity, Alleles, Atherosclerosis, Coronary Artery Disease, Databases, Genetic, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Prevalence, Risk Factors|
OBJECTIVE: A large body of epidemiologic data strongly suggests an association between excess adiposity and coronary artery disease (CAD). Low adiponectin levels, a hormone secreted only from adipocytes, have been associated with an increased risk of CAD in observational studies. However, these associations cannot clarify whether this relationship is causal or due to a shared set of causal factors or even confounding. Genome-wide association studies have identified common variants that influence adiponectin levels, providing valuable tools to examine the genetic relationship between adiponectin and CAD.
METHODS: Using 145 genome wide significant SNPs for adiponectin from the ADIPOGen consortium (n = 49,891), we tested whether adiponectin-decreasing alleles influenced risk of CAD in the CARDIoGRAM consortium (n = 85,274).
RESULTS: In single-SNP analysis, 5 variants among 145 SNPs were associated with increased risk of CAD after correcting for multiple testing (P
CONCLUSION: These findings demonstrate that adiponectin levels and CAD have a shared allelic architecture and provide rationale to undertake a Mendelian randomization studies to understand if this relationship is causal.
|PubMed Central ID||PMC6139652|
|Grant List||090532 / / Wellcome Trust / United Kingdom |
098498 / / Wellcome Trust / United Kingdom
Z99 AG999999 / / Intramural NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada