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Lipoprotein-associated phospholipase A2 and venous thromboembolism: a prospective study.

TitleLipoprotein-associated phospholipase A2 and venous thromboembolism: a prospective study.
Publication TypeJournal Article
Year of Publication2013
AuthorsFolsom AR, Lutsey PL, Roetker NS, Ballantyne CM, Hoogeveen RC, Rosamond WD
Secondary AuthorsCushman M
Corporate AuthorsAtherosclerosis Risk in Communities(ARIC) study
JournalThromb Res
Volume132
Issue1
Pagination44-6
Date Published2013 Jul
ISSN1879-2472
Keywords1-Alkyl-2-acetylglycerophosphocholine Esterase, Aged, Cholesterol, LDL, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Venous Thromboembolism
Abstract

INTRODUCTION: Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory marker associated positively with atherothrombotic risk. Whether Lp-PLA2 is related to risk of venous thromboembolism (VTE) is incompletely studied.

METHODS: We assessed Lp-PLA2 activity in 10,687 Atherosclerosis Risk in Communities (ARIC) Study participants and followed them a median of 8.3 years (from 1996-98 through 2005) for VTE occurrence (n=226).

RESULTS: There was no significant association between baseline Lp-PLA2 quartiles and risk of VTE, neither overall nor stratified as provoked or unprovoked. Adjusted for other risk factors, the hazard ratios (95% confidence interval) of total VTE across quartiles of Lp-PLA2 were 1.0 (reference), 0.95 (0.64, 1.42), 1.03 (0.69, 1.56), and 1.26 (0.83, 1.91). In the subset of participants with LDL-cholesterol ≥130 mg/dL, hazard ratios of total VTE were 1.00, 1.39 (0.44, 4.44), 2.45 (0.84, 7.11), and 2.84 (0.99, 8.14).

CONCLUSION: Our study does not support the overall hypothesis that elevated Lp-PLA2 contributes to VTE occurrence in the general population. However, in the presence of high LDL-cholesterol there was some evidence that Lp-PLA2 may increase VTE risk.

DOI10.1016/j.thromres.2013.05.014
Alternate JournalThromb Res
PubMed ID23746626
PubMed Central IDPMC3742644
Grant ListHHSN268201100005C / / PHS HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
R01 HL59367 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States