|Title||Chronic inflammation role in the obesity-diabetes association: a case-cohort study.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Luft VC, Schmidt MI, Pankow JS, Couper DJ, Ballantyne CM, Young HJ|
|Secondary Authors||Duncan BB|
|Journal||Diabetol Metab Syndr|
|Date Published||2013 Jun 27|
BACKGROUND: Chronic inflammation is related to both obesity and diabetes. Our aim was to investigate to what extent this inflammation contributes to the association between obesity and diabetes.
METHODS: Using a case-cohort design, we followed 567 middle-aged individuals who developed diabetes and 554 who did not over 9 years within the ARIC Study. Weighted Cox proportional hazards analyses permitted statistical inference to the entire cohort.
RESULTS: Obese individuals (BMI≥30 kg/m2), compared to those with BMI
CONCLUSIONS: The marked decrease in the obesity-diabetes association after taking into account inflammation markers and adipokines indicates their major role in the pathways leading to adult onset of diabetes in obese individuals.
|Alternate Journal||Diabetol Metab Syndr|
|PubMed Central ID||PMC3698103|