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Chronic inflammation role in the obesity-diabetes association: a case-cohort study.

TitleChronic inflammation role in the obesity-diabetes association: a case-cohort study.
Publication TypeJournal Article
Year of Publication2013
AuthorsLuft VC, Schmidt MI, Pankow JS, Couper DJ, Ballantyne CM, Young HJ
Secondary AuthorsDuncan BB
JournalDiabetol Metab Syndr
Volume5
Issue1
Pagination31
Date Published2013 Jun 27
ISSN1758-5996
Abstract

BACKGROUND: Chronic inflammation is related to both obesity and diabetes. Our aim was to investigate to what extent this inflammation contributes to the association between obesity and diabetes.

METHODS: Using a case-cohort design, we followed 567 middle-aged individuals who developed diabetes and 554 who did not over 9 years within the ARIC Study. Weighted Cox proportional hazards analyses permitted statistical inference to the entire cohort.

RESULTS: Obese individuals (BMI≥30 kg/m2), compared to those with BMI

CONCLUSIONS: The marked decrease in the obesity-diabetes association after taking into account inflammation markers and adipokines indicates their major role in the pathways leading to adult onset of diabetes in obese individuals.

DOI10.1186/1758-5996-5-31
Alternate JournalDiabetol Metab Syndr
PubMed ID23806173
PubMed Central IDPMC3698103