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Post-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study.

TitlePost-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study.
Publication TypeJournal Article
Year of Publication2013
AuthorsDumitrescu L, Carty CL, Franceschini N, Hindorff LA, Cole SA, Bůžková P, Schumacher FR, Eaton CB, Goodloe RJ, Duggan DJ, Haessler J, Cochran B, Henderson BE, Cheng I, Johnson KC, Carlson CS, Love S-A, Brown-Gentry K, Nato AQ, Quibrera M, Anderson G, Shohet RV, Ambite JLuis, Wilkens LR, Le Marchand L, Haiman CA, Buyske S, Kooperberg C, North KE, Fornage M
Secondary AuthorsCrawford DC
JournalAnn Hum Genet
Volume77
Issue5
Pagination416-25
Date Published2013 Sep
ISSN1469-1809
KeywordsAdult, Aged, European Continental Ancestry Group, Female, Genetic Association Studies, Genome-Wide Association Study, Humans, Lipids, Male, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Quantitative Trait, Heritable, Risk Factors
Abstract

Numerous common genetic variants that influence plasma high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride distributions have been identified via genome-wide association studies (GWAS). However, whether or not these associations are age-dependent has largely been overlooked. We conducted an association study and meta-analysis in more than 22,000 European Americans between 49 previously identified GWAS variants and the three lipid traits, stratified by age (males:

DOI10.1111/ahg.12027
Alternate JournalAnn Hum Genet
PubMed ID23808484
PubMed Central IDPMC3796061
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01-HC-05187 / HC / NHLBI NIH HHS / United States
R01 HL080295 / HL / NHLBI NIH HHS / United States
U01HG004790 / HG / NHGRI NIH HHS / United States
32105-6 / / PHS HHS / United States
N01-HC-45205 / HC / NHLBI NIH HHS / United States
U01CA98758 / CA / NCI NIH HHS / United States
N01HV48195 / HL / NHLBI NIH HHS / United States
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T32 GM080178 / GM / NIGMS NIH HHS / United States
R01 AG015928 / AG / NIA NIH HHS / United States
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85079 / / PHS HHS / United States
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32100-2 / / PHS HHS / United States
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24152 / / PHS HHS / United States
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42129-32 / / PHS HHS / United States
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