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The association of plasma lactate with incident cardiovascular outcomes: the ARIC Study.

TitleThe association of plasma lactate with incident cardiovascular outcomes: the ARIC Study.
Publication TypeJournal Article
Year of Publication2013
AuthorsMatsushita K, Williams EK, Mongraw-Chaffin ML, Coresh JJ, Schmidt M I, Brancati FL, Hoogeveen RC, Ballantyne CM
Secondary AuthorsYoung HJ
JournalAm J Epidemiol
Volume178
Issue3
Pagination401-9
Date Published2013 Aug 01
ISSN1476-6256
KeywordsAlcohol Drinking, Biomarkers, Community-Based Participatory Research, Comorbidity, Coronary Disease, Diabetes Mellitus, Female, Follow-Up Studies, Heart Failure, Humans, Incidence, Lactic Acid, Male, Middle Aged, Obesity, Proportional Hazards Models, Smoking, Stroke, Survival Rate, United States
Abstract

We examined the association of plasma lactate at rest, a marker of oxidative capacity, with incident cardiovascular outcomes in 10,006 participants in the Atherosclerosis Risk in Communities (ARIC) Study visit 4 (1996-1998). We used Cox proportional-hazards models to estimate hazard ratios of incident coronary heart disease, stroke, heart failure, and all-cause mortality by quartiles of plasma lactate (Q1, ≤5.3 mg/dL; Q2, 5.4-6.6; Q3, 6.7-8.6; and Q4 ≥8.7). During a median follow-up time of 10.7 years, there were 1,105 coronary heart disease cases, 379 stroke cases, 820 heart failure cases, and 1,408 deaths. A significant graded relation between lactate level and cardiovascular events was observed in the demographically adjusted model (all P for trend 

DOI10.1093/aje/kwt002
Alternate JournalAm J Epidemiol
PubMed ID23817916
PubMed Central IDPMC3727342
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
P30 DK079637 / DK / NIDDK NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
R01 DK085458 / DK / NIDDK NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States