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Genome-wide association of body fat distribution in African ancestry populations suggests new loci.

TitleGenome-wide association of body fat distribution in African ancestry populations suggests new loci.
Publication TypeJournal Article
Year of Publication2013
AuthorsLiu C-T, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen W-M, Chen F, Henderson BE, Millikan RC, Ambrosone CB, Strom SS, Guo X, Andrews JS, Sun YV, Mosley TH, Yanek LR, Shriner D, Haritunians T, Rotter JI, Speliotes EK, Smith M, Rosenberg L, Mychaleckyj J, Nayak U, Spruill I, W Garvey T, Pettaway C, Nyante S, Bandera EV, Britton AF, Zonderman AB, Rasmussen-Torvik LJ, Chen Y-D I, Ding J, Lohman K, Kritchevsky SB, Zhao W, Peyser PA, Kardia SLR, Kabagambe E, Broeckel U, Chen G, Zhou J, Wassertheil-Smoller S, Neuhouser ML, Rampersaud E, Psaty B, Kooperberg C, Manson JAE, Kuller LH, Ochs-Balcom HM, Johnson KC, Sucheston L, Ordovas JM, Palmer JR, Haiman CA, McKnight B, Howard BV, Becker DM, Bielak LF, Liu Y, Allison MA, Grant SFA, Burke GL, Patel SR, Schreiner PJ, Borecki IB, Evans MK, Taylor H, Sale MM, Howard V, Carlson CS, Rotimi CN, Cushman M, Harris TB, Reiner AP, L Cupples A, North KE
Secondary AuthorsFox CS
JournalPLoS Genet
Volume9
Issue8
Paginatione1003681
Date Published2013
ISSN1553-7404
KeywordsAdiposity, African Continental Ancestry Group, Body Fat Distribution, European Continental Ancestry Group, Female, Genetic Loci, Genome-Wide Association Study, Humans, Male, Obesity, Polymorphism, Single Nucleotide, Waist-Hip Ratio
Abstract

Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat distribution among those of predominantly African ancestry (AA). We performed GWAS of WC and WHR, adjusted and unadjusted for BMI, in up to 33,591 and 27,350 AA individuals, respectively. We identified loci associated with fat distribution in AA individuals using meta-analyses of GWA results for WC and WHR (stage 1). Overall, 25 SNPs with single genomic control (GC)-corrected p-values

DOI10.1371/journal.pgen.1003681
Alternate JournalPLoS Genet
PubMed ID23966867
PubMed Central IDPMC3744443
Grant ListCA54281 / CA / NCI NIH HHS / United States
N01-HB-72992 / HB / NHLBI NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
N01-HB-97068 / HB / NHLBI NIH HHS / United States
R01-HL-088215 / HL / NHLBI NIH HHS / United States
N01-HB-97053 / HB / NHLBI NIH HHS / United States
N01-HB-72997 / HB / NHLBI NIH HHS / United States
N01-HB-73003 / HB / NHLBI NIH HHS / United States
32105-6 / / PHS HHS / United States
N01-HC-45205 / HC / NHLBI NIH HHS / United States
UL1RR033176 / RR / NCRR NIH HHS / United States
UL1TR000124 / TR / NCATS NIH HHS / United States
P30 ES010126 / ES / NIEHS NIH HHS / United States
ES007784 / ES / NIEHS NIH HHS / United States
N01WH22110 / WH / WHI NIH HHS / United States
N01-HC-05187 / HC / NHLBI NIH HHS / United States
N01-HC-4804 / HC / NHLBI NIH HHS / United States
R01-HL-071252 / HL / NHLBI NIH HHS / United States
HL59684 / HL / NHLBI NIH HHS / United States
S06GM008016-380111 / GM / NIGMS NIH HHS / United States
U01 NS041588 / NS / NINDS NIH HHS / United States
R01-HL-071258 / HL / NHLBI NIH HHS / United States
UL1 TR000150 / TR / NCATS NIH HHS / United States
U01 HL053934 / HL / NHLBI NIH HHS / United States
MD002249 / MD / NIMHD NIH HHS / United States
UL1-RR-025005 / RR / NCRR NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
HL071025-01A1 / HL / NHLBI NIH HHS / United States
CA1326792 / CA / NCI NIH HHS / United States
S06GM008016-320107 / GM / NIGMS NIH HHS / United States
N01-HB-7299 / HB / NHLBI NIH HHS / United States
R01 DK084350 / DK / NIDDK NIH HHS / United States
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