Title | Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Franceschini N, Fox E, Zhang Z, et al. |
Secondary Authors | Zhu X |
Corporate Authors | Asian Genetic Epidemiology Network Consortium |
Journal | Am J Hum Genet |
Volume | 93 |
Issue | 3 |
Pagination | 545-54 |
Date Published | 2013 Sep 05 |
ISSN | 1537-6605 |
Keywords | Africa, African Continental Ancestry Group, Blood Pressure, Cohort Studies, Databases, Genetic, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Quantitative Trait, Heritable, Reproducibility of Results |
Abstract | High blood pressure (BP) is more prevalent and contributes to more severe manifestations of cardiovascular disease (CVD) in African Americans than in any other United States ethnic group. Several small African-ancestry (AA) BP genome-wide association studies (GWASs) have been published, but their findings have failed to replicate to date. We report on a large AA BP GWAS meta-analysis that includes 29,378 individuals from 19 discovery cohorts and subsequent replication in additional samples of AA (n = 10,386), European ancestry (EA) (n = 69,395), and East Asian ancestry (n = 19,601). Five loci (EVX1-HOXA, ULK4, RSPO3, PLEKHG1, and SOX6) reached genome-wide significance (p |
DOI | 10.1016/j.ajhg.2013.07.010 |
Alternate Journal | Am J Hum Genet |
PubMed ID | 23972371 |
PubMed Central ID | PMC3769920 |
Grant List | P20 GM103534 / GM / NIGMS NIH HHS / United States R01 HG003054 / HG / NHGRI NIH HHS / United States U01 AG009740 / AG / NIA NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States P20 MD006899 / MD / NIMHD NIH HHS / United States R01 HL055673 / HL / NHLBI NIH HHS / United States |