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Elevated high-sensitivity C-reactive protein as a risk marker of the attenuated relationship between serum cholesterol and cardiovascular events at older age. The ARIC Study.

TitleElevated high-sensitivity C-reactive protein as a risk marker of the attenuated relationship between serum cholesterol and cardiovascular events at older age. The ARIC Study.
Publication TypeJournal Article
Year of Publication2013
AuthorsWhelton SP, Roy P, Astor BC, Zhang L, Hoogeveen RC, Ballantyne CM
Secondary AuthorsCoresh JJ
JournalAm J Epidemiol
Volume178
Issue7
Pagination1076-84
Date Published2013 Oct 01
ISSN1476-6256
KeywordsAge Factors, Aged, Biomarkers, C-Reactive Protein, Cholesterol, Cholesterol, LDL, Coronary Disease, Female, Humans, Incidence, Male, Middle Aged, Multicenter Studies as Topic, Risk Factors, Sex Factors, Socioeconomic Factors, United States
Abstract

The relationship between cholesterol and coronary heart disease (CHD) is attenuated at older age. We analyzed cholesterol level as a predictor of CHD in 8,947 participants from the Atherosclerosis Risk in Communities (ARIC) Study, a large multicenter cohort study that enrolled participants in 1987-1989 at 4 field centers in Washington County, Maryland; Forsyth County, North Carolina; Jackson, Mississippi; and Minneapolis, Minnesota. Participants in the present analysis had no history of CHD and were stratified by age (

DOI10.1093/aje/kwt086
Alternate JournalAm J Epidemiol
PubMed ID24026395
PubMed Central IDPMC3783092
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States