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A common biological basis of obesity and nicotine addiction.

TitleA common biological basis of obesity and nicotine addiction.
Publication TypeJournal Article
Year of Publication2013
AuthorsThorgeirsson TE, Gudbjartsson DF, Sulem P, Besenbacher S, Styrkarsdottir U, Thorleifsson G, Walters GB, Furberg H, Sullivan PF, Marchini J, McCarthy MI, Steinthorsdottir V, Thorsteinsdottir U
Secondary AuthorsStefansson K
Corporate AuthorsTAG Consortium, Oxford-GSK Consortium, ENGAGE consortium
JournalTransl Psychiatry
Volume3
Paginatione308
Date Published2013 Oct 01
ISSN2158-3188
KeywordsAge of Onset, Behavior, Addictive, Body Mass Index, Humans, Iceland, Obesity, Polymorphism, Single Nucleotide, Smoking, Tobacco Use Disorder
Abstract

Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34,216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 × 10(-7)). These findings replicate in a second large data set (N=127,274, thereof 76,242 smokers) for both SI (P=1.2 × 10(-5)) and CPD (P=9.3 × 10(-5)). Notably, the variant most strongly associated with BMI (rs1558902-A in FTO) did not associate with smoking behavior. The association with smoking behavior is not due to the effect of the SNPs on BMI. Our results strongly point to a common biological basis of the regulation of our appetite for tobacco and food, and thus the vulnerability to nicotine addiction and obesity.

DOI10.1038/tp.2013.81
Alternate JournalTransl Psychiatry
PubMed ID24084939
PubMed Central IDPMC3818010
Grant ListR01-DA017932 / DA / NIDA NIH HHS / United States
R01 DA022522 / DA / NIDA NIH HHS / United States
R01 DA017932 / DA / NIDA NIH HHS / United States
R01-DA022522 / DA / NIDA NIH HHS / United States
ETM/75 / / Chief Scientist Office / United Kingdom
090532 / / Wellcome Trust / United Kingdom
CZB/4/540 / / Chief Scientist Office / United Kingdom
ETM/137 / / Chief Scientist Office / United Kingdom
R01 DA018673 / DA / NIDA NIH HHS / United States
G0800675 / / Medical Research Council / United Kingdom
G0600329 / / Medical Research Council / United Kingdom