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No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population.

TitleNo evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population.
Publication TypeJournal Article
Year of Publication2013
AuthorsDumitrescu L, Carty CL, Franceschini N, Hindorff LA, Cole SA, Bůžková P, Schumacher FR, Eaton CB, Goodloe RJ, Duggan DJ, Haessler J, Cochran B, Henderson BE, Cheng I, Johnson KC, Carlson CS, Love S-A, Brown-Gentry K, Nato AQ, Quibrera M, Shohet RV, Ambite JLuis, Wilkens LR, Le Marchand L, Haiman CA, Buyske S, Kooperberg C, North KE, Fornage M
Secondary AuthorsCrawford DC
JournalHum Genet
Volume132
Issue12
Pagination1427-31
Date Published2013 Dec
ISSN1432-1203
KeywordsCholesterol, HDL, Cholesterol, LDL, Cohort Studies, Ethnic Groups, Female, Gene Frequency, Gene-Environment Interaction, Genetics, Population, Genome-Wide Association Study, Humans, Lipid Metabolism, Male, Polymorphism, Single Nucleotide, Prevalence, Smoking, Triglycerides, Young Adult
Abstract

Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.

DOI10.1007/s00439-013-1375-3
Alternate JournalHum Genet
PubMed ID24100633
PubMed Central IDPMC3895337
Grant ListN0144221 / / PHS HHS / United States
N01-HC-05187 / HC / NHLBI NIH HHS / United States
U01CA98758 / CA / NCI NIH HHS / United States
U01 HL65520 / HL / NHLBI NIH HHS / United States
T32 GM080178 / GM / NIGMS NIH HHS / United States
U01 HG004790 / HG / NHGRI NIH HHS / United States
N01-HC-48047 / HC / NHLBI NIH HHS / United States
U01 HL65521 / HL / NHLBI NIH HHS / United States
U01 HG004802 / HG / NHGRI NIH HHS / United States
U01 HL41642 / HL / NHLBI NIH HHS / United States
N01WH32100-2 / WH / WHI NIH HHS / United States
U01CA136792 / CA / NCI NIH HHS / United States
N01WH32108-9 / WH / WHI NIH HHS / United States
U01HG004803 / HG / NHGRI NIH HHS / United States
AG-20098 / AG / NIA NIH HHS / United States
N01-HC-95095 / HC / NHLBI NIH HHS / United States
U01HG004802 / HG / NHGRI NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States
N01WH42107-26 / WH / WHI NIH HHS / United States
N01-HC-48050 / HC / NHLBI NIH HHS / United States
U01 HL41654 / HL / NHLBI NIH HHS / United States
AG-027058 / AG / NIA NIH HHS / United States
N01 HC-55222 / HC / NHLBI NIH HHS / United States
U01 HL41652 / HL / NHLBI NIH HHS / United States
N01WH32122 / WH / WHI NIH HHS / United States
U01 HG004803 / HG / NHGRI NIH HHS / United States
N01-HC-48049 / HC / NHLBI NIH HHS / United States
U01HG004798 / HG / NHGRI NIH HHS / United States
N01-HC-75150 / HC / NHLBI NIH HHS / United States
N01WH32105-6 / WH / WHI NIH HHS / United States
N01HC-15103 / HC / NHLBI NIH HHS / United States
N01WH32111-13 / WH / WHI NIH HHS / United States
N01WH32118-32119 / WH / WHI NIH HHS / United States
U01HG004801 / HG / NHGRI NIH HHS / United States
R37CA54281 / CA / NCI NIH HHS / United States
N0142129-32 / / PHS HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
U01HG004790 / HG / NHGRI NIH HHS / United States
U01 HG004798 / HG / NHGRI NIH HHS / United States
HL080295 / HL / NHLBI NIH HHS / United States
N01-HC-85239 / HC / NHLBI NIH HHS / United States
N01-HC-48048 / HC / NHLBI NIH HHS / United States
AG-023629 / AG / NIA NIH HHS / United States
R01 HL109301 / HL / NHLBI NIH HHS / United States
N01WH32115 / WH / WHI NIH HHS / United States
P30 CA071789 / CA / NCI NIH HHS / United States
P01CA33619 / CA / NCI NIH HHS / United States
N01WH24152 / WH / WHI NIH HHS / United States
R01 CA63 / CA / NCI NIH HHS / United States
U01 HG004801 / HG / NHGRI NIH HHS / United States