Title | No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Dumitrescu L, Carty CL, Franceschini N, Hindorff LA, Cole SA, Bůžková P, Schumacher FR, Eaton CB, Goodloe RJ, Duggan DJ, Haessler J, Cochran B, Henderson BE, Cheng I, Johnson KC, Carlson CS, Love S-A, Brown-Gentry K, Nato AQ, Quibrera M, Shohet RV, Ambite JLuis, Wilkens LR, Le Marchand L, Haiman CA, Buyske S, Kooperberg C, North KE, Fornage M |
Secondary Authors | Crawford DC |
Journal | Hum Genet |
Volume | 132 |
Issue | 12 |
Pagination | 1427-31 |
Date Published | 2013 Dec |
ISSN | 1432-1203 |
Keywords | Cholesterol, HDL, Cholesterol, LDL, Cohort Studies, Ethnic Groups, Female, Gene Frequency, Gene-Environment Interaction, Genetics, Population, Genome-Wide Association Study, Humans, Lipid Metabolism, Male, Polymorphism, Single Nucleotide, Prevalence, Smoking, Triglycerides, Young Adult |
Abstract | Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions. |
DOI | 10.1007/s00439-013-1375-3 |
Alternate Journal | Hum Genet |
PubMed ID | 24100633 |
PubMed Central ID | PMC3895337 |
Grant List | N0144221 / / PHS HHS / United States N01-HC-05187 / HC / NHLBI NIH HHS / United States U01CA98758 / CA / NCI NIH HHS / United States U01 HL65520 / HL / NHLBI NIH HHS / United States T32 GM080178 / GM / NIGMS NIH HHS / United States U01 HG004790 / HG / NHGRI NIH HHS / United States N01-HC-48047 / HC / NHLBI NIH HHS / United States U01 HL65521 / HL / NHLBI NIH HHS / United States U01 HG004802 / HG / NHGRI NIH HHS / United States U01 HL41642 / HL / NHLBI NIH HHS / United States N01WH32100-2 / WH / WHI NIH HHS / United States U01CA136792 / CA / NCI NIH HHS / United States N01WH32108-9 / WH / WHI NIH HHS / United States U01HG004803 / HG / NHGRI NIH HHS / United States AG-20098 / AG / NIA NIH HHS / United States N01-HC-95095 / HC / NHLBI NIH HHS / United States U01HG004802 / HG / NHGRI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01WH42107-26 / WH / WHI NIH HHS / United States N01-HC-48050 / HC / NHLBI NIH HHS / United States U01 HL41654 / HL / NHLBI NIH HHS / United States AG-027058 / AG / NIA NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States U01 HL41652 / HL / NHLBI NIH HHS / United States N01WH32122 / WH / WHI NIH HHS / United States U01 HG004803 / HG / NHGRI NIH HHS / United States N01-HC-48049 / HC / NHLBI NIH HHS / United States U01HG004798 / HG / NHGRI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01WH32105-6 / WH / WHI NIH HHS / United States N01HC-15103 / HC / NHLBI NIH HHS / United States N01WH32111-13 / WH / WHI NIH HHS / United States N01WH32118-32119 / WH / WHI NIH HHS / United States U01HG004801 / HG / NHGRI NIH HHS / United States R37CA54281 / CA / NCI NIH HHS / United States N0142129-32 / / PHS HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States U01HG004790 / HG / NHGRI NIH HHS / United States U01 HG004798 / HG / NHGRI NIH HHS / United States HL080295 / HL / NHLBI NIH HHS / United States N01-HC-85239 / HC / NHLBI NIH HHS / United States N01-HC-48048 / HC / NHLBI NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States R01 HL109301 / HL / NHLBI NIH HHS / United States N01WH32115 / WH / WHI NIH HHS / United States P30 CA071789 / CA / NCI NIH HHS / United States P01CA33619 / CA / NCI NIH HHS / United States N01WH24152 / WH / WHI NIH HHS / United States R01 CA63 / CA / NCI NIH HHS / United States U01 HG004801 / HG / NHGRI NIH HHS / United States |