Title | Retinol binding protein 4 and incident diabetes--the Atherosclerosis Risk in Communities Study (ARIC Study). |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Luft VC, Pereira M, Pankow JS, Ballantyne CM, Couper DJ, Heiss G |
Secondary Authors | Duncan BB |
Corporate Authors | ARIC Investigators |
Journal | Rev Bras Epidemiol |
Volume | 16 |
Issue | 2 |
Pagination | 388-97 |
Date Published | 2013 Jun |
ISSN | 1980-5497 |
Keywords | African Americans, Atherosclerosis, Cohort Studies, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Fasting, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Retinol-Binding Proteins, Plasma, Risk Assessment, Time Factors |
Abstract | BACKGROUND: Retinol binding protein 4 (RBP4) has been described as a link between impaired glucose uptake in adipocytes and systemic insulin sensitivity. OBJECTIVE: To determine whether RBP4 fasting levels predict the development of type 2 diabetes. METHODS: Using a case-cohort design, we followed 543 middle-aged individuals who developed diabetes and 537 who did not over ~9 years within the population-based Atherosclerosis Risk in Communities Study. Weighted Cox proportional hazards analyses permitted statistical inference of the RBP4 - incident diabetes associations to the entire cohort. RESULTS: Women in the highest tertile of RBP4 presented greater risk of developing diabetes (HR = 1.74; 95%CI 1.03 - 2.94) in analyses adjusted for age, ethnicity, study center, parental history of diabetes, hypertension, glomerular filtration rate, body mass index, waist-hip ratio, nonesterified fatty acids, adiponectin, leptin, triglycerides and HDL-C. When additionally adjusted for fasting insulin, this association's significance became borderline (HR = 1.68; 95%CI 1.00 - 2.82). No association between RBP4 levels and incident diabetes was found in men. CONCLUSION: These findings suggest that RBP4 levels may be directly involved in the pathogenesis of type 2 diabetes in women. |
DOI | 10.1590/S1415-790X2013000200014 |
Alternate Journal | Rev Bras Epidemiol |
PubMed ID | 24142010 |
PubMed Central ID | PMC4929996 |
Grant List | N01HC55020 / HL / NHLBI NIH HHS / United States N01HC55018 / HL / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01HC55022 / HL / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01HC55015 / HL / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01HC55016 / HL / NHLBI NIH HHS / United States R01-DK56918 / DK / NIDDK NIH HHS / United States N01HC55019 / HL / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01HC55021 / HL / NHLBI NIH HHS / United States R01 DK056918 / DK / NIDDK NIH HHS / United States |