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Risk factors for incident hyperuricemia during mid-adulthood in African American and white men and women enrolled in the ARIC cohort study.

TitleRisk factors for incident hyperuricemia during mid-adulthood in African American and white men and women enrolled in the ARIC cohort study.
Publication TypeJournal Article
Year of Publication2013
AuthorsMcAdams-Demarco MA, Law A, Maynard JW, Coresh JJ
Secondary AuthorsBaer AN
JournalBMC Musculoskelet Disord
Volume14
Pagination347
Date Published2013 Dec 11
ISSN1471-2474
KeywordsAfrican Americans, Cohort Studies, European Continental Ancestry Group, Female, Humans, Hyperuricemia, Incidence, Male, Middle Aged, Prospective Studies, Risk Assessment, Risk Factors, United States, Uric Acid
Abstract

BACKGROUND: Increased serum urate levels are associated with poor outcomes including but not limited to gout. It is unclear whether serum urate levels are the sole predictor of incident hyperuricemia or whether demographic and clinical risk factors also predict the development of hyperuricemia. The goal of this study was to identify risk factors for incident hyperuricemia over 9 years in a population-based study, ARIC.

METHODS: ARIC recruited individuals from 4 US communities; 8,342 participants who had urate levels 7.0 g/dL) were identified using an AIC-based selection approach in a modified Poisson regression model.

RESULTS: The 9-year cumulative incidence of hyperuricemia was 4%; men = 5%; women = 3%; African Americans = 6% and whites = 3%. The adjusted model included 9 predictors for incident hyperuricemia over 9 years: male sex (RR = 1.73 95% CI: 1.36-2.21), African-American race (RR = 1.79 95% CI: 1.37-2.33), smoking (RR = 1.27, 95% CI: 0.97-1.67),

CONCLUSION: Demographic and clinical risk factors that are routinely collected as part of regular medical care are jointly associated with the development of hyperuricemia.

DOI10.1186/1471-2474-14-347
Alternate JournalBMC Musculoskelet Disord
PubMed ID24330409
PubMed Central IDPMC3878839
Grant ListHHSN268201100005C / / PHS HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States