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Racial differences in gout incidence in a population-based cohort: Atherosclerosis Risk in Communities Study.

TitleRacial differences in gout incidence in a population-based cohort: Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2014
AuthorsMaynard JW, McAdams-Demarco MA, Law A, Kao L, Gelber AC, Coresh JJ
Secondary AuthorsBaer AN
JournalAm J Epidemiol
Volume179
Issue5
Pagination576-83
Date Published2014 Mar 01
ISSN1476-6256
KeywordsAfrican Continental Ancestry Group, European Continental Ancestry Group, Female, Gout, Humans, Incidence, Male, Middle Aged, Proportional Hazards Models, Risk Factors, Sex Factors, United States, Uric Acid
Abstract

We examined racial differences in gout incidence among black and white participants in a longitudinal, population-based cohort and tested whether racial differences were explained by higher levels of serum urate. The Atherosclerosis Risk in Communities Study is a prospective, US population-based cohort study of middle-aged adults enrolled between 1987 and 1989 with ongoing annual follow-up through 2012. We estimated the adjusted hazard ratios and 95% confidence intervals of incident gout by race among 11,963 men and women using adjusted Cox proportional hazards models. The cohort was 23.6% black. The incidence rate of gout was 8.4 per 10,000 person-years (15.5/10,000 person-years for black men, 12.0/10,000 person-years for black women, 9.4/10,000 person-years for white men, and 5.0/10,000 person-years for white women; P

DOI10.1093/aje/kwt299
Alternate JournalAm J Epidemiol
PubMed ID24335384
PubMed Central IDPMC3927975
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
UL1 TR001079 / TR / NCATS NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States