|Title||Insulin resistance and incident heart failure the ARIC study (Atherosclerosis Risk in Communities).|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Vardeny O, Gupta DK, Claggett B, Burke S, Shah A, Loehr LR, Rasmussen-Torvik L, Selvin E, Chang PP, Aguilar D|
|Secondary Authors||Solomon SD|
|Journal||JACC Heart Fail|
|Date Published||2013 Dec|
|Keywords||Atherosclerosis, Female, Heart Failure, Humans, Incidence, Insulin Resistance, Male, Middle Aged, Obesity, Prospective Studies, Risk Factors, United States|
OBJECTIVES: This study was designed to assess the relationship between insulin resistance and incident heart failure (HF) in a community-based cohort.
BACKGROUND: Diabetes mellitus increases the risk for HF, but the association between insulin resistance and HF in individuals without diabetes is unclear.
METHODS: We prospectively analyzed 12,606 participants without diabetes mellitus, prevalent HF, or history of myocardial infarction at baseline (1987 to 1989) from the ARIC (Atherosclerosis Risk in Communities) study. We assessed the relationship between insulin resistance and incident HF using the homeostatic model assessment of insulin resistance (HOMA-IR) equation, adjusting for age, sex, race, body mass index, smoking, hypertension, center, and interim myocardial infarction. We tested for interactions by age, sex, obesity, and race.
RESULTS: Participants with insulin resistance, defined as HOMA-IR ≥2.5 (n = 4,810, 39%), were older, more likely female, African American, hypertensive, and had a higher body mass index as compared with those without insulin resistance. There were 1,455 incident HF cases during a median of 20.6 years of follow-up. Insulin resistance defined by this threshold was not significantly associated with an increased risk for incident HF after adjustment (hazard ratio: 1.08, 95% confidence interval: 0.95 to 1.23). However, when analyzed continuously, this relationship was nonlinear, which indicated that risk increased, and was significantly associated with incident HF between HOMA-IR of 1.0 to 2.0, adjusting for baseline covariates; however, values over 2.5 were not associated with additional increased risk in adjusted models.
CONCLUSIONS: In a community cohort, insulin resistance, defined by lower levels of HOMA-IR than previously considered, was associated with an increased risk for HF.
|Alternate Journal||JACC Heart Fail|
|PubMed Central ID||PMC3893700|
|Grant List||HHSN268201100012C / HL / NHLBI NIH HHS / United States |
K08 HL116792 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States