| Title | Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Tragante V, Barnes MR, Ganesh SK, et al. |
| Secondary Authors | Keating BJ |
| Journal | Am J Hum Genet |
| Volume | 94 |
| Issue | 3 |
| Pagination | 349-60 |
| Date Published | 2014 Mar 06 |
| ISSN | 1537-6605 |
| Keywords | Arterial Pressure, Blood Pressure, Computational Biology, Diastole, Europe, European Continental Ancestry Group, Genetic Loci, Genetics, Population, Genome-Wide Association Study, Genotype, Humans, Phenotype, Polymorphism, Single Nucleotide, Quality Control, Quantitative Trait Loci, Risk Factors, Systole |
| Abstract | Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ~50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p |
| DOI | 10.1016/j.ajhg.2013.12.016 |
| Alternate Journal | Am J Hum Genet |
| PubMed ID | 24560520 |
| PubMed Central ID | PMC3951943 |
| Grant List | PG/09/022/26739 / BHF_ / British Heart Foundation / United Kingdom UL1 TR000064 / TR / NCATS NIH HHS / United States U01 GM074492 / GM / NIGMS NIH HHS / United States R37 AG011099 / AG / NIA NIH HHS / United States R01 HL088120 / HL / NHLBI NIH HHS / United States P30 DK072488 / DK / NIDDK NIH HHS / United States MC_UU_12013/1 / MRC_ / Medical Research Council / United Kingdom 090532 / WT_ / Wellcome Trust / United Kingdom G0902313 / MRC_ / Medical Research Council / United Kingdom MC_UU_12013/8 / MRC_ / Medical Research Council / United Kingdom SP/08/002/24118 / BHF_ / British Heart Foundation / United Kingdom G9521010 / MRC_ / Medical Research Council / United Kingdom G0802432 / MRC_ / Medical Research Council / United Kingdom FS/11/35/28871 / BHF_ / British Heart Foundation / United Kingdom R01 AG021917 / AG / NIA NIH HHS / United States FS/12/33/29561 / BHF_ / British Heart Foundation / United Kingdom R01 AG016592 / AG / NIA NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States PG/07/085/23349 / BHF_ / British Heart Foundation / United Kingdom R01 HL074730 / HL / NHLBI NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States FS/14/12/30540 / BHF_ / British Heart Foundation / United Kingdom FS/12/8/29377 / BHF_ / British Heart Foundation / United Kingdom MR/K006584/1 / MRC_ / Medical Research Council / United Kingdom MR/K013351/1 / MRC_ / Medical Research Council / United Kingdom |