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Chronic kidney disease, lipids and apolipoproteins, and coronary heart disease: the ARIC study.

TitleChronic kidney disease, lipids and apolipoproteins, and coronary heart disease: the ARIC study.
Publication TypeJournal Article
Year of Publication2014
AuthorsLamprea-Montealegre JA, Sharrett ARichey, Matsushita K, Selvin E, Szklo M
Secondary AuthorsAstor BC
Date Published2014 May
KeywordsAged, Apolipoproteins, Cohort Studies, Coronary Disease, Female, Humans, Lipids, Male, Middle Aged, Renal Insufficiency, Chronic, Risk Factors

BACKGROUND: Chronic kidney disease (CKD) is associated with elevated apolipoprotein B to A-1 ratio (ApoB/A1). It is not known whether these markers are more strongly associated with the risk of coronary heart disease (CHD) in CKD compared to traditionally measured lipids and lipoprotein cholesterol ratios.

METHODS: We studied the association of lipids and apolipoproteins including non-HDL-cholesterol to HDL-cholesterol ratio (NonHDLc/HDLc) and ApoB/A1 with incident CHD in 10,137 individuals free of CHD at baseline (visit four) in the Atherosclerosis Risk in Communities (ARIC) study. An estimated glomerular filtration rate of 15 to

RESULTS: CKD was present in 1217 (12%) individuals free of CHD at baseline. The median follow-up time was 11.1 years. A CHD event developed in 498 out of 8920 individuals without CKD (incidence rate: 5.2 events per 1000 person-years) and in 138 out of 1217 individuals with CKD (incidence rate: 12.0 events per 1000 person-years; P 0.1) when comparing these estimates to those of participants without CKD.

CONCLUSIONS: Although CKD is associated with a lower ApoA1 concentration and with a higher ApoB/A1, we found no evidence that these apolipoproteins are more strongly associated with CHD incidence in CKD compared to NonHDLc/HDLc.

Alternate JournalAtherosclerosis
PubMed ID24607852
Grant ListHHSN268201100005C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States