Pulse lineResearch With Heart Logo

Genetic determinants influencing human serum metabolome among African Americans.

TitleGenetic determinants influencing human serum metabolome among African Americans.
Publication TypeJournal Article
Year of Publication2014
AuthorsYu B, Zheng Y, Alexander D, Morrison AC, Coresh JJ
Secondary AuthorsBoerwinkle E
JournalPLoS Genet
Volume10
Issue3
Paginatione1004212
Date Published2014 Mar
ISSN1553-7404
KeywordsAcetyltransferases, African Americans, Alleles, Atherosclerosis, Diabetes Mellitus, Genome-Wide Association Study, Humans, Metabolome, Phenotype, Polymorphism, Single Nucleotide, Trehalose
Abstract

Phenotypes proximal to gene action generally reflect larger genetic effect sizes than those that are distant. The human metabolome, a result of multiple cellular and biological processes, are functional intermediate phenotypes proximal to gene action. Here, we present a genome-wide association study of 308 untargeted metabolite levels among African Americans from the Atherosclerosis Risk in Communities (ARIC) Study. Nineteen significant common variant-metabolite associations were identified, including 13 novel loci (p

DOI10.1371/journal.pgen.1004212
Alternate JournalPLoS Genet
PubMed ID24625756
PubMed Central IDPMC3952826
Grant ListR01HL59367 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100009C / / PHS HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
R01HL087641 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
HG004402 / HG / NHGRI NIH HHS / United States
R01HL086694 / HL / NHLBI NIH HHS / United States