Pulse lineResearch With Heart Logo

Short-term repeatability of electrocardiographic Tpeak-Tend and QT intervals.

TitleShort-term repeatability of electrocardiographic Tpeak-Tend and QT intervals.
Publication TypeJournal Article
Year of Publication2014
AuthorsGellert KS, Rautaharju P, Snyder ML, Whitsel EA, Matsushita K, Heiss G
Secondary AuthorsSoliman EZ
JournalJ Electrocardiol
Volume47
Issue3
Pagination356-61
Date Published2014 May-Jun
ISSN1532-8430
KeywordsAlgorithms, Data Interpretation, Statistical, Diagnosis, Computer-Assisted, Electrocardiography, Female, Heart Rate, Humans, Male, Reference Values, Reproducibility of Results, Sensitivity and Specificity
Abstract

BACKGROUND: The electrocardiographic (ECG) Tpeak-Tend interval (TpTe) is associated with arrhythmias and sudden cardiac death. TpTe offers a supplementary measure for the QT interval (QT), yet its repeatability has not been established.

PURPOSE: Evaluate short-term repeatability of TpTe and QT.

METHODS: Four ECGs were obtained on sixty participants. The sources of variation, intra-class correlation coefficient (ICC) - an index of reproducibility - and minimal detectable change (MDC) were estimated for TpTe and QT. The impact of repeated measurements on repeatability was estimated for a hypothetical clinical trial designed to detect drug-induced prolongation of TpTe and QT.

RESULTS: We used heart rate-adjusted QT [(QT)a] but TpTe in the study group was rate-invariant. The ICC [95% confidence interval (CI)] was 0.77 (0.69, 0.85) for TpTe, 0.75 (0.65, 0.85) for QT and 0.60 (0.47, 0.73) for (QT)a. The MDC (ms) was 21, 32 and 26 for TpTe, QT and (QT)a respectively.

CONCLUSION: TpTe has excellent repeatability supporting its use as a supplement to QT in observational and clinical studies.

DOI10.1016/j.jelectrocard.2014.03.002
Alternate JournalJ Electrocardiol
PubMed ID24792986
PubMed Central IDPMC4025961
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
F31 HL120595 / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
T32 HL-007055 / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States
T32 HL007055 / HL / NHLBI NIH HHS / United States