Pulse lineResearch With Heart Logo

Smoking behavior and lung cancer in a biracial cohort: the Atherosclerosis Risk in Communities study.

TitleSmoking behavior and lung cancer in a biracial cohort: the Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2014
AuthorsPrizment AE, Yatsuya H, Lutsey PL, Lubin JH, Woodward M, Folsom AR
Secondary AuthorsHuxley RR
JournalAm J Prev Med
Volume46
Issue6
Pagination624-32
Date Published2014 Jun
ISSN1873-2607
KeywordsAfrican Americans, Age Factors, Cohort Studies, European Continental Ancestry Group, Female, Follow-Up Studies, Health Status Disparities, Humans, Incidence, Lung Neoplasms, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Risk, Sex Factors, Smoking, Smoking Cessation, Time Factors, United States
Abstract

BACKGROUND: In the U.S., the incidence of lung cancer varies by race, with rates being highest among black men. There are marked differences in smoking behavior between blacks and whites, but little is known regarding how these differences contribute to the racial disparities in lung cancer.

PURPOSE: To compare the lung cancer risk associated with smoking in 14,610 blacks and whites in the prospective cohort Atherosclerosis Risk in Communities study.

METHODS: Smoking characteristics were ascertained at baseline and three follow-up visits in 1990-1992, 1993-1995, and 1996-1998 (response rates were 93%, 86%, and 80%, respectively), as well as from annual telephone interviews. Data were analyzed in the fall of 2012. Multivariable-adjusted proportional hazards models were used to calculate hazard ratios and 95% CIs for lung cancer.

RESULTS: Over 20 years of follow-up (1987-2006), 470 incident cases of lung cancer occurred. Lung cancer incident rates were highest in black men and lowest in black women. However, there was no evidence to support racial differences in the associations of smoking status, intensity, or age at initiation with lung cancer risk (all p(interaction)≥0.25). The hazard ratio for those who started smoking at age ≤12 versus >22 years was 3.03 (95% CI=1.62, 5.67). Prolonged smoking cessation (≥10 years) was associated with a decrease in lung cancer risk, with equivalent benefits in whites and blacks, 84% and 74%, respectively (p(interaction)=0.25).

CONCLUSIONS: Smoking confers similar lung cancer risk in blacks and whites.

DOI10.1016/j.amepre.2014.01.017
Alternate JournalAm J Prev Med
PubMed ID24842739
PubMed Central IDPMC4030495
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
T32CA132670 / CA / NCI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
KL2 TR000113 / TR / NCATS NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
/ / Intramural NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
T32 CA132670 / CA / NCI NIH HHS / United States
U01 CA164975 / CA / NCI NIH HHS / United States
U01 CA164975-01 / CA / NCI NIH HHS / United States