|Title||Effect of genetic variants associated with plasma homocysteine levels on stroke risk.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Cotlarciuc I, Malik R, Holliday EG, Ahmadi KR, Paré G, Psaty BM, Fornage M, Hasan N, Rinne PE, M Ikram A, Markus HS, Rosand J, Mitchell BD, Kittner SJ, Meschia JF, van Meurs JBJ, Uitterlinden AG, Worrall BB, Dichgans M|
|Secondary Authors||Sharma P|
|Corporate Authors||METASTROKE and the International Stroke Genetics Consortium|
|Date Published||2014 Jul|
|Keywords||Brain Ischemia, Cohort Studies, Europe, Genetic Association Studies, Genetic Loci, Genetic Predisposition to Disease, Genetic Variation, Genome, Homocysteine, Humans, Polymorphism, Single Nucleotide, Risk, Stroke|
BACKGROUND AND PURPOSE: Elevated total plasma homocysteine (tHcy) levels are known to be associated with increased risk of ischemic stroke (IS). Given that both tHcy and IS are heritable traits, we investigated a potential genetic relationship between homocysteine levels and stroke risk by assessing 18 polymorphisms previously associated with tHcy levels for their association with IS and its subtypes.
METHODS: Previous meta-analysis results from an international stroke collaborative network, METASTROKE, were used to assess association of the 18 tHcy-associated single-nucleotide polymorphisms (SNPs) in 12 389 IS cases and 62 004 controls. We also investigated the associations in regions located within 50 kb from the 18 tHcy-related SNPs and the association of a genetic risk score, including the 18 SNPs.
RESULTS: One SNP located in the RASIP1 gene and a cluster of 3 SNPs located at and near SLC17A3 were significantly associated with IS (P
CONCLUSIONS: This study found several potential associations with IS and its subtypes: an association of an MUT variant with small-vessel disease, an MTHFR variant with large-vessel disease, and associations of RASIP1 and SLC17A3 variants with overall IS.
|PubMed Central ID||PMC4083192|
|Grant List|| / / Medical Research Council / United Kingdom |
/ / Department of Health / United Kingdom
P30 DK072488 / DK / NIDDK NIH HHS / United States
Z99 OD999999 / / Intramural NIH HHS / United States
/ / Wellcome Trust / United Kingdom