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Genome-wide association analysis identifies six new loci associated with forced vital capacity.

TitleGenome-wide association analysis identifies six new loci associated with forced vital capacity.
Publication TypeJournal Article
Year of Publication2014
AuthorsLoth DW, Artigas MSoler, Gharib SA, et al.
Secondary AuthorsLondon SJ
JournalNat Genet
Volume46
Issue7
Pagination669-77
Date Published2014 Jul
ISSN1546-1718
KeywordsCohort Studies, Databases, Genetic, Follow-Up Studies, Forced Expiratory Volume, Genetic Loci, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Humans, Lung Diseases, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Prognosis, Quantitative Trait Loci, Respiratory Function Tests, Spirometry, Vital Capacity
Abstract

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P

DOI10.1038/ng.3011
Alternate JournalNat Genet
PubMed ID24929828
PubMed Central IDPMC4140093
Grant ListETM/55 / / Chief Scientist Office / United Kingdom
CZB/4/505 / / Chief Scientist Office / United Kingdom
CZB/4/710 / / Chief Scientist Office / United Kingdom
G0100266 / / Medical Research Council / United Kingdom
UL1 TR001079 / TR / NCATS NIH HHS / United States
R25 MH083620 / MH / NIMH NIH HHS / United States
R01 HL077612 / HL / NHLBI NIH HHS / United States
G1000861 / / Medical Research Council / United Kingdom
MR/L016400/1 / / Medical Research Council / United Kingdom
UL1 TR000124 / TR / NCATS NIH HHS / United States
MR/K026992/1 / / Medical Research Council / United Kingdom
MC_UU_12015/1 / / Medical Research Council / United Kingdom
R01 HL105756 / HL / NHLBI NIH HHS / United States
MC_U106179471 / / Medical Research Council / United Kingdom
P30 DK063491 / DK / NIDDK NIH HHS / United States
U01 AG023749 / AG / NIA NIH HHS / United States
MC_PC_U127592696 / / Medical Research Council / United Kingdom
G0701863 / / Medical Research Council / United Kingdom
CZD/16/6/4 / / Chief Scientist Office / United Kingdom
MC_PC_U127561128 / / Medical Research Council / United Kingdom
G0902313 / / Medical Research Council / United Kingdom
U01 AG023746 / AG / NIA NIH HHS / United States
G0700704 / / Medical Research Council / United Kingdom
BB/F019394/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom
Z01 ES043012-10 / / Intramural NIH HHS / United States
R01 HL103676 / HL / NHLBI NIH HHS / United States
R01 HL117078 / HL / NHLBI NIH HHS / United States
R01 AG023629 / AG / NIA NIH HHS / United States
SRF/01/010 / / Department of Health / United Kingdom