Title | Genome-wide association analysis identifies six new loci associated with forced vital capacity. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Loth DW, Artigas MSoler, Gharib SA, et al. |
Secondary Authors | London SJ |
Journal | Nat Genet |
Volume | 46 |
Issue | 7 |
Pagination | 669-77 |
Date Published | 2014 Jul |
ISSN | 1546-1718 |
Keywords | Cohort Studies, Databases, Genetic, Follow-Up Studies, Forced Expiratory Volume, Genetic Loci, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Humans, Lung Diseases, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Prognosis, Quantitative Trait Loci, Respiratory Function Tests, Spirometry, Vital Capacity |
Abstract | Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P |
DOI | 10.1038/ng.3011 |
Alternate Journal | Nat Genet |
PubMed ID | 24929828 |
PubMed Central ID | PMC4140093 |
Grant List | ETM/55 / / Chief Scientist Office / United Kingdom CZB/4/505 / / Chief Scientist Office / United Kingdom CZB/4/710 / / Chief Scientist Office / United Kingdom G0100266 / / Medical Research Council / United Kingdom UL1 TR001079 / TR / NCATS NIH HHS / United States R25 MH083620 / MH / NIMH NIH HHS / United States R01 HL077612 / HL / NHLBI NIH HHS / United States G1000861 / / Medical Research Council / United Kingdom MR/L016400/1 / / Medical Research Council / United Kingdom UL1 TR000124 / TR / NCATS NIH HHS / United States MR/K026992/1 / / Medical Research Council / United Kingdom MC_UU_12015/1 / / Medical Research Council / United Kingdom R01 HL105756 / HL / NHLBI NIH HHS / United States MC_U106179471 / / Medical Research Council / United Kingdom P30 DK063491 / DK / NIDDK NIH HHS / United States U01 AG023749 / AG / NIA NIH HHS / United States MC_PC_U127592696 / / Medical Research Council / United Kingdom G0701863 / / Medical Research Council / United Kingdom CZD/16/6/4 / / Chief Scientist Office / United Kingdom MC_PC_U127561128 / / Medical Research Council / United Kingdom G0902313 / / Medical Research Council / United Kingdom U01 AG023746 / AG / NIA NIH HHS / United States G0700704 / / Medical Research Council / United Kingdom BB/F019394/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom Z01 ES043012-10 / / Intramural NIH HHS / United States R01 HL103676 / HL / NHLBI NIH HHS / United States R01 HL117078 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States SRF/01/010 / / Department of Health / United Kingdom |