| Title | Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV, Yang M-L, Zhang Y, Ehret G, Rose LM, Hwang S-J, Papanicolau GJ, Sijbrands EJ, Rice K, Eiriksdottir G, Pihur V, Ridker PM, Vasan RS, Newton-Cheh C, Raffel LJ, Amin N, Rotter JI, Liu K, Launer LJ, Xu M, Caulfield M, Morrison AC, Johnson AD, Vaidya D, Dehghan A, Li G, Bouchard C, Harris TB, Zhang H, Boerwinkle E, Siscovick DS, Gao W, Uitterlinden AG, Rivadeneira F, Hofman A, Willer CJ, Franco OH, Huo Y, Witteman JCM, Munroe PB, Gudnason V, Palmas W, van Duijn C, Fornage M, Levy D, Psaty BM |
| Secondary Authors | Chakravarti A |
| Corporate Authors | Global Blood Pressure Genetics Consortium |
| Journal | Am J Hum Genet |
| Volume | 95 |
| Issue | 1 |
| Pagination | 49-65 |
| Date Published | 2014 Jul 03 |
| ISSN | 1537-6605 |
| Keywords | Blood Pressure, Genome-Wide Association Study, Humans, Longitudinal Studies, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci |
| Abstract | Blood pressure (BP) is a heritable, quantitative trait with intraindividual variability and susceptibility to measurement error. Genetic studies of BP generally use single-visit measurements and thus cannot remove variability occurring over months or years. We leveraged the idea that averaging BP measured across time would improve phenotypic accuracy and thereby increase statistical power to detect genetic associations. We studied systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) averaged over multiple years in 46,629 individuals of European ancestry. We identified 39 trait-variant associations across 19 independent loci (p |
| DOI | 10.1016/j.ajhg.2014.06.002 |
| Alternate Journal | Am J Hum Genet |
| PubMed ID | 24975945 |
| PubMed Central ID | PMC4085637 |
| Grant List | G9521010 / / Medical Research Council / United Kingdom G1000143 / / Medical Research Council / United Kingdom UL1 TR000124 / TR / NCATS NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States 14136 / / Cancer Research UK / United Kingdom G0401527 / / Medical Research Council / United Kingdom MR/K006584/1 / / Medical Research Council / United Kingdom |